Sökning: onr:"swepub:oai:gup.ub.gu.se/297596" > Genomic and drug ta...
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000 | 12256naa a2201489 4500 | |
001 | oai:gup.ub.gu.se/297596 | |
003 | SwePub | |
008 | 240528s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-424065 | |
009 | oai:lup.lub.lu.se:9a451a80-186c-48e3-984d-ad6861a35aa6 | |
009 | oai:prod.swepub.kib.ki.se:145007830 | |
024 | 7 | a https://gup.ub.gu.se/publication/2975962 URI |
024 | 7 | a https://doi.org/10.1038/s42255-020-00287-22 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4240652 URI |
024 | 7 | a https://lup.lub.lu.se/record/9a451a80-186c-48e3-984d-ad6861a35aa62 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1450078302 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Folkersen, Lasseu Danish National Genome Center4 aut |
245 | 1 0 | a Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals. |
264 | c 2020-10-16 | |
264 | 1 | b Springer Science and Business Media LLC,c 2020 |
500 | a De tre första författarna delar förstaförfattarskapetDe tre sista författarna delar sistaförfattarskapet | |
520 | a Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Gustafsson, Stefanu Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi4 aut0 (Swepub:lu)extLU-1433 |
700 | 1 | a Wang, Qinu University of Oulu4 aut |
700 | 1 | a Hansen, Daniel Hvidbergu Intomics A/S4 aut |
700 | 1 | a Hedman, Åsa Ku Karolinska Institutet,Karolinska Institute,Pfizer Limited, UK4 aut |
700 | 1 | a Schork, Andrewu Translational Genomics Research Institute (TGen)4 aut |
700 | 1 | a Page, Karenu Pfizer Inc. US4 aut |
700 | 1 | a Zhernakova, Daria Vu University of Groningen4 aut |
700 | 1 | a Wu, Yangu University of Queensland4 aut |
700 | 1 | a Peters, Jamesu Imperial College London,University of Cambridge4 aut |
700 | 1 | a Eriksson, Niclas,d 1978-u Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)nieri103 |
700 | 1 | a Bergen, Sarah Eu Karolinska Institutet,Karolinska Institute4 aut |
700 | 1 | a Boutin, Thibaud Su University of Edinburgh4 aut |
700 | 1 | a Bretherick, Andrew Du SCALLOP consortium4 aut |
700 | 1 | a Enroth, Stefan,d 1976-u Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Gyllensten4 aut0 (Swepub:uu)stenr451 |
700 | 1 | a Kalnapenkis, Anetteu SCALLOP consortium4 aut |
700 | 1 | a Gådin, Jesper Ru Karolinska Institutet4 aut |
700 | 1 | a Suur, Bianca Eu Karolinska Institutet4 aut |
700 | 1 | a Chen, Yanu Karolinska Institutet,Karolinska Institute4 aut |
700 | 1 | a Matic, Ljubicau Karolinska Institutet4 aut |
700 | 1 | a Gale, Jeremy Du SCALLOP consortium4 aut |
700 | 1 | a Lee, Julieu SCALLOP consortium4 aut |
700 | 1 | a Zhang, Weidongu SCALLOP consortium4 aut |
700 | 1 | a Quazi, Amirau SCALLOP consortium4 aut |
700 | 1 | a Ala-Korpela, Mikau SCALLOP consortium4 aut |
700 | 1 | a Choi, Seung Hoanu SCALLOP consortium4 aut |
700 | 1 | a Claringbould, Anniqueu SCALLOP consortium4 aut |
700 | 1 | a Danesh, Johnu SCALLOP consortium4 aut |
700 | 1 | a Davey Smith, Georgeu SCALLOP consortium4 aut |
700 | 1 | a de Masi, Federicou SCALLOP consortium4 aut |
700 | 1 | a Elmståhl, Sölveu Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-sel |
700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-gen |
700 | 1 | a Fauman, Eric4 aut |
700 | 1 | a Fernandez, Celineu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medk-cfe |
700 | 1 | a Franke, Lude4 aut |
700 | 1 | a Franks, Paul Wu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517 |
700 | 1 | a Haley, Chris4 aut |
700 | 1 | a Hamsten, Andersu Karolinska Institutet4 aut |
700 | 1 | a Ingason, Andres4 aut |
700 | 1 | a Johansson, Åsau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik4 aut0 (Swepub:uu)asjoh108 |
700 | 1 | a Joshi, Peter K4 aut |
700 | 1 | a Lind, Larsu Uppsala universitet,Klinisk epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Lindgren, Cecilia Mu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Cardiovascular Research - Hypertension,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medf-mma |
700 | 1 | a Lubitz, Steven4 aut |
700 | 1 | a Palmer, Tom4 aut |
700 | 1 | a Macdonald-Dunlop, Erin4 aut |
700 | 1 | a Nilsson, Peter Mu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Michaëlsson, Karl,d 1959-u Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)karlmich |
700 | 1 | a Morris, Andrew P4 aut |
700 | 1 | a Mägi, Reedik4 aut |
700 | 1 | a Nagle, Michael W4 aut |
700 | 1 | a Nilsson, Peter M4 aut |
700 | 1 | a Nilsson, Janu Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-jni |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Prins, Bram4 aut |
700 | 1 | a Pålsson, Erik4 aut |
700 | 1 | a Qi, Ting4 aut |
700 | 1 | a Sjögren, Marketau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Genetic and Molecular Epidemiology,Lund University Research Groups,Cardiovascular Research - Hypertension,Skåne University Hospital4 aut0 (Swepub:lu)endo-msj |
700 | 1 | a Sundström, Johan,c Professor,d 1971-u Uppsala universitet,Klinisk epidemiologi,The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia4 aut0 (Swepub:uu)johasund |
700 | 1 | a Surendran, Praveen4 aut |
700 | 1 | a Võsa, Urmo4 aut |
700 | 1 | a Werge, Thomas4 aut |
700 | 1 | a Wernersson, Rasmus4 aut |
700 | 1 | a Westra, Harm-Jan4 aut |
700 | 1 | a Yang, Jian4 aut |
700 | 1 | a Zhernakova, Alexandra4 aut |
700 | 1 | a Ärnlöv, Johanu Karolinska Institutet4 aut |
700 | 1 | a Fu, Jingyuan4 aut |
700 | 1 | a Smith, Gustavu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molecular Epidemiology and Cardiology,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine4 aut0 (Swepub:lu)med-gvs |
700 | 1 | a Esko, Tõnu4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Siegbahn, Agneta,d 1947-u Uppsala universitet,Klinisk kemi4 aut0 (Swepub:uu)agsie424 |
700 | 1 | a Wilson, James F4 aut |
700 | 1 | a Wallentin, Lars,d 1943-u Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall |
700 | 1 | a Butterworth, Adam S4 aut |
700 | 1 | a Holmes, Michael V4 aut |
700 | 1 | a Ingelsson, Erik4 aut |
700 | 1 | a Mälarstig, Andersu Karolinska Institutet4 aut |
710 | 2 | a Danish National Genome Centerb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Nature metabolismd : Springer Science and Business Media LLCg 2:10, s. 1135-1148q 2:10<1135-1148x 2522-5812 |
856 | 4 | u https://pure.rug.nl/ws/files/194787127/Genomic_and_drug_target_evaluation_of_90_cardiovascular_proteins_in_30_931_individuals.pdf |
856 | 4 | u https://portal.research.lu.se/files/100206750/Folkersen_2020.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1038/s42255-020-00287-2y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/297596 |
856 | 4 8 | u https://doi.org/10.1038/s42255-020-00287-2 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-424065 |
856 | 4 8 | u https://lup.lub.lu.se/record/9a451a80-186c-48e3-984d-ad6861a35aa6 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145007830 |
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