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  • D'Angiolo, M.Université Côte d'Azur,University of Côte d'Azur (author)

A yeast living ancestor reveals the origin of genomic introgressions

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-11-11
  • Springer Science and Business Media LLC,2020

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  • LIBRIS-ID:oai:gup.ub.gu.se/298306
  • https://gup.ub.gu.se/publication/298306URI
  • https://doi.org/10.1038/s41586-020-2889-1DOI
  • https://research.chalmers.se/publication/526136URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • A yeast clonal descendant of an ancient hybridization event is identified and sheds light on the early evolution of the Saccharomyces cerevisiae Alpechin lineage and its abundant Saccharomyces paradoxus introgressions. Genome introgressions drive evolution across the animal(1), plant(2) and fungal(3) kingdoms. Introgressions initiate from archaic admixtures followed by repeated backcrossing to one parental species. However, how introgressions arise in reproductively isolated species, such as yeast(4), has remained unclear. Here we identify a clonal descendant of the ancestral yeast hybrid that founded the extant Saccharomyces cerevisiae Alpechin lineage(5), which carries abundant Saccharomyces paradoxus introgressions. We show that this clonal descendant, hereafter defined as a 'living ancestor', retained the ancestral genome structure of the first-generation hybrid with contiguous S. cerevisiae and S. paradoxus subgenomes. The ancestral first-generation hybrid underwent catastrophic genomic instability through more than a hundred mitotic recombination events, mainly manifesting as homozygous genome blocks generated by loss of heterozygosity. These homozygous sequence blocks rescue hybrid fertility by restoring meiotic recombination and are the direct origins of the introgressions present in the Alpechin lineage. We suggest a plausible route for introgression evolution through the reconstruction of extinct stages and propose that genome instability allows hybrids to overcome reproductive isolation and enables introgressions to emerge.

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  • De Chiara, M.Université Côte d'Azur,University of Côte d'Azur (author)
  • Yue, J. X.Université Côte d'Azur,University of Côte d'Azur (author)
  • Irizar, A.Université Côte d'Azur,University of Côte d'Azur (author)
  • Stenberg, SimonGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg,Norges miljø- og biovitenskapelige universitet (NMBU),Norwegian University of Life Sciences (NMBU) (author)
  • Persson, Karl,1988Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:cth)karperss (author)
  • Llored, A.Université Côte d'Azur,University of Côte d'Azur (author)
  • Barre, B.Université Côte d'Azur,University of Côte d'Azur (author)
  • Schacherer, J.Université de Strasbourg,University of Strasbourg (author)
  • Marangoni, R.Universita di Pisa,University of Pisa (author)
  • Gilson, E.Université Côte d'Azur,University of Côte d'Azur (author)
  • Warringer, Jonas,1973Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg(Swepub:gu)xwarrj (author)
  • Liti, G.Université Côte d'Azur,University of Côte d'Azur (author)
  • Université Côte d'AzurInstitutionen för kemi och molekylärbiologi (creator_code:org_t)

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  • In:Nature: Springer Science and Business Media LLC587, s. 420-4250028-08361476-4687

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