Sökning: onr:"swepub:oai:gup.ub.gu.se/298984" > ATN incorporating c...
Fältnamn | Indikatorer | Metadata |
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000 | 03589naa a2200457 4500 | |
001 | oai:gup.ub.gu.se/298984 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2989842 URI |
024 | 7 | a https://doi.org/10.1002/alz.122332 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Cousins, Katheryn A Q4 aut |
245 | 1 0 | a ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration. |
264 | c 2020-11-23 | |
264 | 1 | b Wiley,c 2021 |
520 | a The ATN framework provides an in vivo diagnosis of Alzheimer's disease (AD) using cerebrospinal fluid (CSF) biomarkers of pathologic amyloid plaques (A), tangles (T), and neurodegeneration (N). ATN is rarely evaluated in pathologically confirmed patients and its poor sensitivity to suspected non-Alzheimer's pathophysiologies (SNAP), including frontotemporal lobar degeneration (FTLD), leads to misdiagnoses. We compared accuracy of ATN (ATNTAU ) using CSF total tau (t-tau) to a modified strategy (ATNNfL ) using CSF neurofilament light chain (NfL) in an autopsy cohort.ATNTAU and ATNNfL were trained in an independent sample and validated in autopsy-confirmed AD (n=67) and FTLD (n=27).ATNNfL more accurately identified FTLD as SNAP (sensitivity=0.93, specificity=0.94) than ATNTAU (sensitivity=0.44, specificity=0.97), even in cases with co-occurring AD and FTLD. ATNNfL misclassified fewer AD and FTLD as "Normal" (2%) than ATNTAU (14%).ATNNfL is a promising diagnostic strategy that may accurately identify both AD and FTLD, even when pathologies co-occur. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Phillips, Jeffrey S4 aut |
700 | 1 | a Irwin, David J4 aut |
700 | 1 | a Lee, Edward B4 aut |
700 | 1 | a Wolk, David A4 aut |
700 | 1 | a Shaw, Leslie M4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Burke, Sarah E4 aut |
700 | 1 | a Kinney, Nikolas G4 aut |
700 | 1 | a Gibbons, Garrett S4 aut |
700 | 1 | a McMillan, Corey T4 aut |
700 | 1 | a Trojanowski, John Q4 aut |
700 | 1 | a Grossman, Murray4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimer's & dementia : the journal of the Alzheimer's Associationd : Wileyg 17:5, s. 822-830q 17:5<822-830x 1552-5279 |
773 | 0 | t Alzheimer's & Dementiad : Wileyg 17:5, s. 822-830q 17:5<822-830x 1552-5260 |
856 | 4 | u https://discovery.ucl.ac.uk/10118879/3/Zetterberg_ATN%20incorporating%20cerebrospinal%20fluid%20neurofilament%20light%20chain%20detects%20frontotemporal%20lobar%20degeneration_AAM.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/298984 |
856 | 4 8 | u https://doi.org/10.1002/alz.12233 |
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