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Both Amyloid-beta P...
Both Amyloid-beta Peptide and Tau Protein Are Affected by an Anti-Amyloid-beta Antibody Fragment in Elderly 3xTg-AD Mice
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Roda, A. R. (författare)
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- Montoliu-Gaya, Laia (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Serra-Mir, G. (författare)
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Villegas, S. (författare)
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(creator_code:org_t)
- 2020-09-10
- 2020
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1422-0067. ; 21:18
- Relaterad länk:
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https://www.mdpi.com...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Alzheimer's disease (AD) is the most common dementia worldwide. According to the amyloid hypothesis, the early accumulation of the A beta-peptide triggers tau phosphorylation, synaptic dysfunction, and eventually neuronal death leading to cognitive impairment, as well as behavioral and psychological symptoms of dementia. ScFv-h3D6 is a single-chain variable fragment that has already shown its ability to diminish the amyloid burden in 5-month-old 3xTg-AD mice. However, tau pathology is not evident at this early stage of the disease in this mouse model. In this study, the effects of scFv-h3D6 on A beta and tau pathologies have been assessed in 22-month-old 3xTg-AD mice. Briefly, 3xTg-AD female mice were treated for 2 weeks with scFv-h3D6 and compared with 3xTg-AD and non-transgenic (NTg) mice treated with PBS. The treatment with scFv-h3D6 was unequivocally effective in reducing the area of A beta staining. Furthermore, a tendency for a reduction in tau levels was also observed after treatment that points to the interplay between A beta and tau pathologies. The pro-inflammatory state observed in the 3xTg-AD mice did not progress after scFv-h3D6 treatment. In addition, the treatment did not alter the levels of apolipoprotein E or apolipoprotein J. Thus, a 2-week treatment with scFv-h3D6 was able to reduce AD-like pathology in elderly 3xTg-AD female mice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Aβ; tau; immunotherapy; Alzheimer; scFv; 3xTg-AD
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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