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Molecular character...
Molecular characteristics of eae-positive clinical Shiga toxin-producing Escherichia coli in Sweden
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- Hua, Y. (author)
- Southern Med Univ, Peoples R China; Karolinska Inst, Sweden
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- Bai, X. G. (author)
- Karolinska Institutet
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- Zhang, J. (author)
- Massey Univ, New Zealand
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- Jernberg, C. (author)
- Publ Hlth Agcy Sweden, Sweden
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- Chromek, M. (author)
- Karolinska Institutet
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- Hansson, Sverker, 1946 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
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- Frykman, Anne, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden
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- Yang, X. (author)
- Chinese Ctr Dis Control & Prevent, Peoples R China
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- Xiong, Y. W. (author)
- Chinese Ctr Dis Control & Prevent, Peoples R China
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- Wan, C. S. (author)
- Southern Med Univ, Peoples R China
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- Matussek, Andreas (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Karolinska Inst, Sweden; Jonkoping Reg Cty, Sweden; Oslo Univ Hosp, Norway; Univ Oslo, Norway
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(creator_code:org_t)
- 2020-12-10
- 2020
- English.
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In: Emerging microbes & infections. - : Informa UK Limited. - 2222-1751. ; 9:1, s. 2562-2570
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Abstract
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- Shiga toxin (Stx)-producing Escherichia coli (STEC) can cause a wide range of symptoms from asymptomatic carriage, mild diarrhea to bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Intimin, encoded by the eae gene, also plays a critical role in STEC pathogenesis. Herein, we investigated the prevalence and genetic diversity of eae among clinical STEC isolates from patients with diarrhea, BD, HUS as well as from asymptomatic STEC-positive individuals in Sweden with whole-genome sequencing. We found that 173 out of 239 (72.4%) of clinical STEC strains were eae positive. Six eae subtypes (epsilon 1, gamma 1, beta 3, theta, zeta and rho) were identified eae and its subtype gamma 1 were significantly overrepresented in O157:H7 strains isolated from BD and HUS patients. epsilon 1 was associated with O121:H19 and O103:H2 strains, and beta 3 to O26:H11 strains. The combination of eae subtype gamma 1 and stx subtype (stx (2) or stx (1)+stx (2)) is more likely to cause severe disease, suggesting the possibility of using eae genotypes in risk assessment of STEC infection. In summary, this study demonstrated a high prevalence of eae in clinical STEC strains and considerable genetic diversity of eae in STEC strains in Sweden from 1994 through 2018, and revealed association between eae subtypes and disease severity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Shiga toxin-producing Escherichia coli
- intimin
- eae gene
- gene
- diversity
- hemolytic uremic syndrome
- clinical significance
- hemolytic-uremic syndrome
- genetic diversity
- intestinal-mucosa
- intimin
- genes
- strains
- subtypes
- germany
- Immunology
- Microbiology
- Shiga toxin-producing Escherichia coli; intimin; eae gene; gene diversity; hemolytic uremic syndrome; clinical significance
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hua, Y.
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Bai, X. G.
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Zhang, J.
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Jernberg, C.
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Chromek, M.
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Hansson, Sverker ...
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Frykman, Anne, 1 ...
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Yang, X.
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Xiong, Y. W.
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Wan, C. S.
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Matussek, Andrea ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Infectious Medic ...
- Articles in the publication
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Emerging microbe ...
- By the university
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University of Gothenburg
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Linköping University
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Karolinska Institutet