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Strong oral plaque ...
Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics
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Ghensi, P. (author)
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Manghi, P. (author)
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Zolfo, M. (author)
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Armanini, F. (author)
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Pasolli, E. (author)
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Bolzan, M. (author)
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Bertelle, A. (author)
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Dell'Acqua, F. (author)
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Dellasega, E. (author)
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Waldner, R. (author)
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Tessarolo, F. (author)
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- Tomasi, Cristiano, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2
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Segata, N. (author)
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(creator_code:org_t)
- 2020-10-30
- 2020
- English.
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In: Npj Biofilms and Microbiomes. - : Springer Science and Business Media LLC. - 2055-5008. ; 6:1
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Dental implants are installed in an increasing number of patients. Mucositis and peri-implantitis are common microbial-biofilm-associated diseases affecting the tissues that surround the dental implant and are a major medical and socioeconomic burden. By metagenomic sequencing of the plaque microbiome in different peri-implant health and disease conditions (113 samples from 72 individuals), we found microbial signatures for peri-implantitis and mucositis and defined the peri-implantitis-related complex (PiRC) composed by the 7 most discriminative bacteria. The peri-implantitis microbiome is site specific as contralateral healthy sites resembled more the microbiome of healthy implants, while mucositis was specifically enriched for Fusobacterium nucleatum acting as a keystone colonizer. Microbiome-based machine learning showed high diagnostic and prognostic power for peri-implant diseases and strain-level profiling identified a previously uncharacterized subspecies of F. nucleatum to be particularly associated with disease. Altogether, we associated the plaque microbiome with peri-implant diseases and identified microbial signatures of disease severity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- Biotechnology & Applied Microbiology
- Microbiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ghensi, P.
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Manghi, P.
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Zolfo, M.
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Armanini, F.
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Pasolli, E.
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Bolzan, M.
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show more...
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Bertelle, A.
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Dell'Acqua, F.
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Dellasega, E.
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Waldner, R.
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Tessarolo, F.
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Tomasi, Cristian ...
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Segata, N.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
- Articles in the publication
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Npj Biofilms and ...
- By the university
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University of Gothenburg