Sökning: onr:"swepub:oai:gup.ub.gu.se/302231" > Downregulation of S...
Fältnamn | Indikatorer | Metadata |
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000 | 05809naa a2200517 4500 | |
001 | oai:gup.ub.gu.se/302231 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-173626 | |
024 | 7 | a https://gup.ub.gu.se/publication/3022312 URI |
024 | 7 | a https://doi.org/10.1016/j.biopsych.2020.08.0272 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1736262 URI |
040 | a (SwePub)gud (SwePub)liu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Barbier, Estelleu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)estba07 |
245 | 1 0 | a Downregulation of Synaptotagmin 1 in the Prelimbic Cortex Drives Alcohol-Associated Behaviors in Rats |
264 | 1 | b Elsevier BV,c 2021 |
500 | a Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [201307434, 2018-028149]; Region Ostergotland; Stiftelsen Psykiatriska Forskningsfonden; Wallenberg FoundationEuropean Commission | |
520 | a Background: Alcohol addiction is characterized by persistent neuroadaptations in brain structures involved in motivation, emotion, and decision making, including the medial prefrontal cortex, the nucleus accumbens, and the amygdala. We previously reported that induction of alcohol dependence was associated with long-term changes in the expression of genes involved in neurotransmitter release. Specifically, Syt1, which plays a key role in neurotransmitter release and neuronal functions, was downregulated. Here, we therefore examined the role of Syt1 in alcohol-associated behaviors in rats. Methods: We evaluated the effect of Syt1 downregulation using an adeno-associated virus (AAV) containing a short hairpin RNA against Syt1. Cre-dependent Syt1 was also used in combination with an rAAV2 retro-Cre virus to assess circuit-specific effects of Syt1 knockdown (KD). Results: Alcohol-induced downregulation of Syt1 is specific to the prelimbic cortex (PL), and KD of Syt1 in the PL resulted in escalated alcohol consumption, increased motivation to consume alcohol, and increased alcohol drinking despite negative consequences (“compulsivity”). Syt1 KD in the PL altered the excitation/inhibition balance in the basolateral amygdala, while the nucleus accumbens core was unaffected. Accordingly, a projection-specific Syt1 KD in the PL–basolateral amygdala projection was sufficient to increase compulsive alcohol drinking, while a KD of Syt1 restricted to PL–nucleus accumbens core projecting neurons had no effect on tested alcohol-related behaviors. Conclusions: Together, these data suggest that dysregulation of Syt1 is an important mechanism in long-term neuroadaptations observed after a history of alcohol dependence, and that Syt1 regulates alcohol-related behaviors in part by affecting a PL–basolateral amygdala brain circuit. © 2020 Society of Biological Psychiatry | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Alcohol addiction | |
653 | a Basolateral amygdala | |
653 | a Compulsivity | |
653 | a Nucleus accumbens | |
653 | a Prelimbic cortex | |
653 | a Syt1 | |
700 | 1 | a Barchiesi, Riccardou Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)ricba75 |
700 | 1 | a Domi, Ana,d 1990u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sweden4 aut0 (Swepub:gu)xdomia |
700 | 1 | a Chanthongdee, Kanatu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Mahidol Univ, Thailand4 aut0 (Swepub:liu)kanch40 |
700 | 1 | a Domi, Esiu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)esido51 |
700 | 1 | a Augier, Gaëlleu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)gaeau73 |
700 | 1 | a Augier, Ericu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten4 aut0 (Swepub:liu)eriau90 |
700 | 1 | a Xu, Liu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Sichuan Prov Peoples Hosp, Peoples R China4 aut0 (Swepub:liu)lixu00 |
700 | 1 | a Adermark, Louise,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sweden4 aut0 (Swepub:gu)xadelo |
700 | 1 | a Heilig, Markusu Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping4 aut0 (Swepub:liu)marhe41 |
710 | 2 | a Linköpings universitetb Centrum för social och affektiv neurovetenskap4 org |
773 | 0 | t Biological Psychiatryd : Elsevier BVg 89:4, s. 398-406q 89:4<398-406x 0006-3223x 1873-2402 |
856 | 4 | u http://www.biologicalpsychiatryjournal.com/article/S0006322320318862/pdf |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1531832/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/302231 |
856 | 4 8 | u https://doi.org/10.1016/j.biopsych.2020.08.027 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173626 |
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