Search: onr:"swepub:oai:gup.ub.gu.se/303213" >
Blood neurofilament...
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
2021-03-20
-
Springer Science and Business Media LLC,2021
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/303213
-
https://gup.ub.gu.se/publication/303213URI
-
https://doi.org/10.1007/s00415-021-10517-6DOI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Objective To test the hypotheses that blood biomarkers for nervous system injury, serum concentrations of neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAp) can serve as biomarkers for disease severity in COVID-19 patients. Methods Forty-seven inpatients with confirmed COVID-19 had blood samples drawn on admission for assessing serum biomarkers of CNS injury by Single molecule array (Simoa), NfL and GFAp. Concentrations of NfL and GFAp were analyzed in relation to symptoms, clinical signs, inflammatory biomarkers and clinical outcomes. We used multivariate linear models to test for differences in biomarker concentrations in the subgroups, accounting for confounding effects. Results In total, 21% (n = 10) of the patients were admitted to an intensive care unit, and the overall mortality rate was 13% (n = 6). Non-survivors had higher serum concentrations of NfL (p < 0.001) upon admission than patients who were discharged alive both in adjusted analyses (p = 2.6 x 10(-7)) and unadjusted analyses (p = 0.001). The concentrations of NfL in non-survivors increased over repeated measurements; whereas, the concentrations in survivors were stable. The GFAp concentration was also significantly higher in non-survivors than survivors (p = 0.02). Conclusion Increased concentrations of NfL and GFAp in COVID-19 patients on admission may indicate increased mortality risk. Measurement of blood biomarkers for nervous system injury can be useful to detect and monitor CNS injury in COVID-19.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Hogestol, E. A.
(author)
-
Popperud, T. H.
(author)
-
Holter, J. C.
(author)
-
Dyrhol-Riise, A. M.
(author)
-
Tonby, K.
(author)
-
Stiksrud, B.
(author)
-
Quist-Paulsen, E.
(author)
-
Berge, T.
(author)
-
Barratt-Due, A.
(author)
-
Aukrust, P.
(author)
-
Heggelund, L.
(author)
-
Blennow, Kaj,1958Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xbleka
(author)
-
Zetterberg, H.
(author)
-
Harbo, H. F.
(author)
-
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Related titles
-
In:Journal of Neurology: Springer Science and Business Media LLC268, s. 3574-35830340-53541432-1459
Internet link
Find in a library
To the university's database
- By the author/editor
-
Aamodt, A. H.
-
Hogestol, E. A.
-
Popperud, T. H.
-
Holter, J. C.
-
Dyrhol-Riise, A. ...
-
Tonby, K.
-
show more...
-
Stiksrud, B.
-
Quist-Paulsen, E ...
-
Berge, T.
-
Barratt-Due, A.
-
Aukrust, P.
-
Heggelund, L.
-
Blennow, Kaj, 19 ...
-
Zetterberg, H.
-
Harbo, H. F.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Journal of Neuro ...
- By the university
-
University of Gothenburg