Search: onr:"swepub:oai:gup.ub.gu.se/309037" >
Four distinct traje...
-
Vogel, Jacob W.McGill University
(author)
Four distinct trajectories of tau deposition identified in Alzheimer’s disease
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
2021-04-29
-
Springer Science and Business Media LLC,2021
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/309037
-
https://gup.ub.gu.se/publication/309037URI
-
https://doi.org/10.1038/s41591-021-01309-6DOI
-
https://lup.lub.lu.se/record/a3e8b18c-1343-4744-b3ff-ca3b1347aeb6URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Young, A. L.King's College London
(author)
-
Oxtoby, N. P.University College London
(author)
-
Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-rsm
(author)
-
Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Academic Medical Center of University of Amsterdam (AMC),Vrije Universiteit Amsterdam(Swepub:lu)ri1513os
(author)
-
Strandberg, Olof T.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)teor-osn
(author)
-
La Joie, R.University of California, San Francisco
(author)
-
Aksman, L. M.University College London
(author)
-
Grothe, Michel J.,1981University of Gothenburg,Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xgromi
(author)
-
Iturria-Medina, Y.McGill University
(author)
-
Weiner, M.
(author)
-
Aisen, P.
(author)
-
Petersen, R.
(author)
-
Jack, Jr.Avid Radiopharmaceuticals, Inc
(author)
-
Jagust, W.
(author)
-
Trojanowki, J. Q.
(author)
-
Toga, A. W.
(author)
-
Beckett, L.
(author)
-
Green, R. C.
(author)
-
Saykin, A. J.
(author)
-
Morris, J.
(author)
-
Shaw, L. M.
(author)
-
Liu, E.
(author)
-
Montine, T.
(author)
-
Thomas, R. G.
(author)
-
Donohue, M.Avid Radiopharmaceuticals, Inc
(author)
-
Walter, S.
(author)
-
Gessert, D.
(author)
-
Sather, T.
(author)
-
Jiminez, G.
(author)
-
Harvey, D.
(author)
-
Bernstein, M.
(author)
-
Fox, N.
(author)
-
Thompson, P.
(author)
-
Schuff, N.
(author)
-
DeCarli, C.
(author)
-
Borowski, B.
(author)
-
Gunter, J.
(author)
-
Senjem, M.
(author)
-
Vemuri, P.
(author)
-
Jones, D.
(author)
-
Kantarci, K.
(author)
-
Ward, C.
(author)
-
Koeppe, R. A.
(author)
-
Foster, N.
(author)
-
Reiman, E. M.
(author)
-
Chen, K.
(author)
-
Mathis, C.
(author)
-
Landau, S.
(author)
-
Cairns, N. J.
(author)
-
Householder, E.
(author)
-
Reinwald, L. T.
(author)
-
Lee, V.
(author)
-
Korecka, M.
(author)
-
Figurski, M.
(author)
-
Crawford, K.
(author)
-
Neu, S.
(author)
-
Foroud, T. M.
(author)
-
Potkin, S.
(author)
-
Shen, L.
(author)
-
Kelley, F.
(author)
-
Kim, S.
(author)
-
Nho, K.
(author)
-
Kachaturian, Z.
(author)
-
Frank, R.
(author)
-
Snyder, P. J.
(author)
-
Molchan, S.
(author)
-
Kaye, J.
(author)
-
Quinn, J.
(author)
-
Lind, B.
(author)
-
Carter, R.
(author)
-
Dolen, S.
(author)
-
Schneider, L. S.
(author)
-
Pawluczyk, S.
(author)
-
Beccera, M.
(author)
-
Teodoro, L.
(author)
-
Spann, B. M.
(author)
-
Brewer, J.
(author)
-
Vanderswag, H.
(author)
-
Fleisher, A.
(author)
-
Heidebrink, J. L.
(author)
-
Lord, J. L.
(author)
-
Mason, S. S.
(author)
-
Albers, C. S.
(author)
-
Knopman, D.
(author)
-
Johnson, K.
(author)
-
Doody, R. S.
(author)
-
Meyer, J. V.
(author)
-
Chowdhury, M.
(author)
-
Rountree, S.
(author)
-
Dang, M.
(author)
-
Stern, Y.
(author)
-
Honig, L. S.
(author)
-
Bell, K. L.
(author)
-
Ances, B.
(author)
-
Morris, J. C.
(author)
-
Carroll, M.
(author)
-
Leon, S.
(author)
-
Mintun, M. A.
(author)
-
Schneider, S.
(author)
-
Oliver, A.
(author)
-
Griffith, R.
(author)
-
Clark, D.University College London
(author)
-
Geldmacher, D.
(author)
-
Brockington, J.
(author)
-
Roberson, E.
(author)
-
Grossman, H.
(author)
-
Mitsis, E.
(author)
-
deToledo-Morrell, L.
(author)
-
Shah, R. C.
(author)
-
Duara, R.University of California, San Francisco
(author)
-
Varon, D.
(author)
-
Greig, M. T.
(author)
-
Roberts, P.
(author)
-
Albert, M.
(author)
-
Onyike, C.
(author)
-
D’Agostino, II
(author)
-
Kielb, S.
(author)
-
Galvin, J. E.
(author)
-
Pogorelec, D. M.
(author)
-
Cerbone, B.
(author)
-
Michel, C. A.
(author)
-
Rusinek, H.
(author)
-
de Leon, M. J.
(author)
-
Glodzik, L.
(author)
-
De Santi, S.
(author)
-
Doraiswamy, P. M.
(author)
-
Petrella, J. R.
(author)
-
Wong, T. Z.
(author)
-
Arnold, S. E.
(author)
-
Karlawish, J. H.
(author)
-
Wolk, D.
(author)
-
Smith, C. D.
(author)
-
Jicha, G.
(author)
-
Hardy, P.
(author)
-
Sinha, P.
(author)
-
Oates, E.
(author)
-
Conrad, G.
(author)
-
Lopez, O. L.
(author)
-
Oakley, M. A.
(author)
-
Simpson, D. M.
(author)
-
Porsteinsson, A. P.
(author)
-
Goldstein, B. S.
(author)
-
Martin, K.
(author)
-
Makino, K. M.
(author)
-
Ismail, M. S.
(author)
-
Brand, C.
(author)
-
Mulnard, R. A.
(author)
-
Thai, G.
(author)
-
McAdams Ortiz, C.
(author)
-
Womack, K.
(author)
-
Mathews, D.
(author)
-
Quiceno, M.
(author)
-
Arrastia, R. D.
(author)
-
King, R.
(author)
-
Weiner, M.
(author)
-
Cook, K. M.
(author)
-
DeVous, M.
(author)
-
Levey, A. I.
(author)
-
Lah, J. J.
(author)
-
Cellar, J. S.
(author)
-
Burns, J. M.
(author)
-
Anderson, H. S.
(author)
-
Swerdlow, R. H.
(author)
-
Apostolova, L.
(author)
-
Tingus, K.
(author)
-
Woo, E.
(author)
-
Silverman, D. H. S.
(author)
-
Lu, P. H.
(author)
-
Bartzokis, G.
(author)
-
Radford, N. R. G.
(author)
-
Parfitt, F.
(author)
-
Kendall, T.
(author)
-
Johnson, H.
(author)
-
Farlow, M. R.
(author)
-
Hake, A. M.
(author)
-
Matthews, B. R.
(author)
-
Herring, S.
(author)
-
Hunt, C.
(author)
-
van Dyck, C. H.
(author)
-
Carson, R. E.
(author)
-
MacAvoy, M. G.
(author)
-
Chertkow, H.
(author)
-
Bergman, H.
(author)
-
Hosein, C.
(author)
-
Black, S.
(author)
-
Stefanovic, B.
(author)
-
Caldwell, C.McGill University
(author)
-
Hsiung, G. Y. R.
(author)
-
Feldman, H.
(author)
-
Mudge, B.
(author)
-
Past, M. A.
(author)
-
Kertesz, A.
(author)
-
Rogers, J.
(author)
-
Trost, D.
(author)
-
Bernick, C.
(author)
-
Munic, D.
(author)
-
Kerwin, D.
(author)
-
Mesulam, M. M.
(author)
-
Lipowski, K.
(author)
-
Wu, C. K.
(author)
-
Johnson, N.
(author)
-
Sadowsky, C.
(author)
-
Martinez, W.
(author)
-
Villena, T.
(author)
-
Turner, R. S.
(author)
-
Johnson, K.
(author)
-
Reynolds, B.
(author)
-
Sperling, R. A.
(author)
-
Johnson, K. A.
(author)
-
Marshall, G.
(author)
-
Frey, M.
(author)
-
Yesavage, J.
(author)
-
Taylor, J. L.
(author)
-
Lane, B.
(author)
-
Rosen, A.
(author)
-
Tinklenberg, J.
(author)
-
Sabbagh, M. N.
(author)
-
Belden, C. M.
(author)
-
Jacobson, S. A.
(author)
-
Sirrel, S. A.
(author)
-
Kowall, N.
(author)
-
Killiany, R.
(author)
-
Budson, A. E.
(author)
-
Norbash, A.
(author)
-
Johnson, P. L.
(author)
-
Obisesan, T. O.
(author)
-
Wolday, S.
(author)
-
Allard, J.
(author)
-
Lerner, A.
(author)
-
Ogrocki, P.
(author)
-
Hudson, L.
(author)
-
Fletcher, E.
(author)
-
Carmichael, O.
(author)
-
Olichney, J.
(author)
-
DeCarli, C.
(author)
-
Kittur, S.
(author)
-
Borrie, M.
(author)
-
Lee, T. Y.
(author)
-
Bartha, R.
(author)
-
Johnson, S.
(author)
-
Asthana, S.
(author)
-
Carlsson, C. M.
(author)
-
Potkin, S. G.
(author)
-
Preda, A.
(author)
-
Nguyen, D.
(author)
-
Tariot, P.
(author)
-
Reeder, S.
(author)
-
Bates, V.
(author)
-
Capote, H.
(author)
-
Rainka, M.
(author)
-
Scharre, D. W.
(author)
-
Kataki, M.
(author)
-
Adeli, A.
(author)
-
Zimmerman, E. A.
(author)
-
Celmins, D.
(author)
-
Brown, A. D.
(author)
-
Pearlson, G. D.
(author)
-
Blank, K.
(author)
-
Anderson, K.
(author)
-
Santulli, R. B.
(author)
-
Kitzmiller, T. J.
(author)
-
Schwartz, E. S.
(author)
-
Sink, K. M.
(author)
-
Williamson, J. D.
(author)
-
Garg, P.
(author)
-
Watkins, F.
(author)
-
Ott, B. R.
(author)
-
Querfurth, H.
(author)
-
Tremont, G.
(author)
-
Salloway, S.
(author)
-
Malloy, P.
(author)
-
Correia, S.
(author)
-
Rosen, H. J.
(author)
-
Miller, B. L.
(author)
-
Mintzer, J.
(author)
-
Spicer, K.
(author)
-
Bachman, D.
(author)
-
Finger, E.
(author)
-
Pasternak, S.
(author)
-
Rachinsky, I.
(author)
-
Drost, D.
(author)
-
Pomara, N.
(author)
-
Hernando, R.
(author)
-
Sarrael, A.
(author)
-
Schultz, S. K.
(author)
-
Ponto, L. L. B.
(author)
-
Shim, H.
(author)
-
Smith, K. E.
(author)
-
Relkin, N.
(author)
-
Chaing, G.
(author)
-
Raudin, L.
(author)
-
Smith, A.
(author)
-
Fargher, K.
(author)
-
Raj, B. A.
(author)
-
Pontecorvo, M. J.
(author)
-
Devous, M. D.
(author)
-
Rabinovici, G. D.
(author)
-
Alexander, D. C.
(author)
-
Lyoo, C. H.Yonsei University
(author)
-
Evans, A. C.
(author)
-
Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
-
McGill UniversityKing's College London
(creator_code:org_t)
Related titles
-
In:Nature Medicine: Springer Science and Business Media LLC27:5, s. 871-8811078-89561546-170X
Internet link
Find in a library
To the university's database
- By the author/editor
-
Vogel, Jacob W.
-
Young, A. L.
-
Oxtoby, N. P.
-
Smith, Ruben
-
Ossenkoppele, Ri ...
-
Strandberg, Olof ...
-
show more...
-
La Joie, R.
-
Aksman, L. M.
-
Grothe, Michel J ...
-
Iturria-Medina, ...
-
Weiner, M.
-
Aisen, P.
-
Petersen, R.
-
Jack, Jr.
-
Jagust, W.
-
Trojanowki, J. Q ...
-
Toga, A. W.
-
Beckett, L.
-
Green, R. C.
-
Saykin, A. J.
-
Morris, J.
-
Shaw, L. M.
-
Liu, E.
-
Montine, T.
-
Thomas, R. G.
-
Donohue, M.
-
Walter, S.
-
Gessert, D.
-
Sather, T.
-
Jiminez, G.
-
Harvey, D.
-
Bernstein, M.
-
Fox, N.
-
Thompson, P.
-
Schuff, N.
-
DeCarli, C.
-
Borowski, B.
-
Gunter, J.
-
Senjem, M.
-
Vemuri, P.
-
Jones, D.
-
Kantarci, K.
-
Ward, C.
-
Koeppe, R. A.
-
Foster, N.
-
Reiman, E. M.
-
Chen, K.
-
Mathis, C.
-
Landau, S.
-
Cairns, N. J.
-
Householder, E.
-
Reinwald, L. T.
-
Lee, V.
-
Korecka, M.
-
Figurski, M.
-
Crawford, K.
-
Neu, S.
-
Foroud, T. M.
-
Potkin, S.
-
Shen, L.
-
Kelley, F.
-
Kim, S.
-
Nho, K.
-
Kachaturian, Z.
-
Frank, R.
-
Snyder, P. J.
-
Molchan, S.
-
Kaye, J.
-
Quinn, J.
-
Lind, B.
-
Carter, R.
-
Dolen, S.
-
Schneider, L. S.
-
Pawluczyk, S.
-
Beccera, M.
-
Teodoro, L.
-
Spann, B. M.
-
Brewer, J.
-
Vanderswag, H.
-
Fleisher, A.
-
Heidebrink, J. L ...
-
Lord, J. L.
-
Mason, S. S.
-
Albers, C. S.
-
Knopman, D.
-
Johnson, K.
-
Doody, R. S.
-
Meyer, J. V.
-
Chowdhury, M.
-
Rountree, S.
-
Dang, M.
-
Stern, Y.
-
Honig, L. S.
-
Bell, K. L.
-
Ances, B.
-
Morris, J. C.
-
Carroll, M.
-
Leon, S.
-
Mintun, M. A.
-
Schneider, S.
-
Oliver, A.
-
Griffith, R.
-
Clark, D.
-
Geldmacher, D.
-
Brockington, J.
-
Roberson, E.
-
Grossman, H.
-
Mitsis, E.
-
deToledo-Morrell ...
-
Shah, R. C.
-
Duara, R.
-
Varon, D.
-
Greig, M. T.
-
Roberts, P.
-
Albert, M.
-
Onyike, C.
-
D’Agostino, II
-
Kielb, S.
-
Galvin, J. E.
-
Pogorelec, D. M.
-
Cerbone, B.
-
Michel, C. A.
-
Rusinek, H.
-
de Leon, M. J.
-
Glodzik, L.
-
De Santi, S.
-
Doraiswamy, P. M ...
-
Petrella, J. R.
-
Wong, T. Z.
-
Arnold, S. E.
-
Karlawish, J. H.
-
Wolk, D.
-
Smith, C. D.
-
Jicha, G.
-
Hardy, P.
-
Sinha, P.
-
Oates, E.
-
Conrad, G.
-
Lopez, O. L.
-
Oakley, M. A.
-
Simpson, D. M.
-
Porsteinsson, A. ...
-
Goldstein, B. S.
-
Martin, K.
-
Makino, K. M.
-
Ismail, M. S.
-
Brand, C.
-
Mulnard, R. A.
-
Thai, G.
-
McAdams Ortiz, C ...
-
Womack, K.
-
Mathews, D.
-
Quiceno, M.
-
Arrastia, R. D.
-
King, R.
-
Cook, K. M.
-
DeVous, M.
-
Levey, A. I.
-
Lah, J. J.
-
Cellar, J. S.
-
Burns, J. M.
-
Anderson, H. S.
-
Swerdlow, R. H.
-
Apostolova, L.
-
Tingus, K.
-
Woo, E.
-
Silverman, D. H. ...
-
Lu, P. H.
-
Bartzokis, G.
-
Radford, N. R. G ...
-
Parfitt, F.
-
Kendall, T.
-
Johnson, H.
-
Farlow, M. R.
-
Hake, A. M.
-
Matthews, B. R.
-
Herring, S.
-
Hunt, C.
-
van Dyck, C. H.
-
Carson, R. E.
-
MacAvoy, M. G.
-
Chertkow, H.
-
Bergman, H.
-
Hosein, C.
-
Black, S.
-
Stefanovic, B.
-
Caldwell, C.
-
Hsiung, G. Y. R.
-
Feldman, H.
-
Mudge, B.
-
Past, M. A.
-
Kertesz, A.
-
Rogers, J.
-
Trost, D.
-
Bernick, C.
-
Munic, D.
-
Kerwin, D.
-
Mesulam, M. M.
-
Lipowski, K.
-
Wu, C. K.
-
Johnson, N.
-
Sadowsky, C.
-
Martinez, W.
-
Villena, T.
-
Turner, R. S.
-
Reynolds, B.
-
Sperling, R. A.
-
Johnson, K. A.
-
Marshall, G.
-
Frey, M.
-
Yesavage, J.
-
Taylor, J. L.
-
Lane, B.
-
Rosen, A.
-
Tinklenberg, J.
-
Sabbagh, M. N.
-
Belden, C. M.
-
Jacobson, S. A.
-
Sirrel, S. A.
-
Kowall, N.
-
Killiany, R.
-
Budson, A. E.
-
Norbash, A.
-
Johnson, P. L.
-
Obisesan, T. O.
-
Wolday, S.
-
Allard, J.
-
Lerner, A.
-
Ogrocki, P.
-
Hudson, L.
-
Fletcher, E.
-
Carmichael, O.
-
Olichney, J.
-
Kittur, S.
-
Borrie, M.
-
Lee, T. Y.
-
Bartha, R.
-
Johnson, S.
-
Asthana, S.
-
Carlsson, C. M.
-
Potkin, S. G.
-
Preda, A.
-
Nguyen, D.
-
Tariot, P.
-
Reeder, S.
-
Bates, V.
-
Capote, H.
-
Rainka, M.
-
Scharre, D. W.
-
Kataki, M.
-
Adeli, A.
-
Zimmerman, E. A.
-
Celmins, D.
-
Brown, A. D.
-
Pearlson, G. D.
-
Blank, K.
-
Anderson, K.
-
Santulli, R. B.
-
Kitzmiller, T. J ...
-
Schwartz, E. S.
-
Sink, K. M.
-
Williamson, J. D ...
-
Garg, P.
-
Watkins, F.
-
Ott, B. R.
-
Querfurth, H.
-
Tremont, G.
-
Salloway, S.
-
Malloy, P.
-
Correia, S.
-
Rosen, H. J.
-
Miller, B. L.
-
Mintzer, J.
-
Spicer, K.
-
Bachman, D.
-
Finger, E.
-
Pasternak, S.
-
Rachinsky, I.
-
Drost, D.
-
Pomara, N.
-
Hernando, R.
-
Sarrael, A.
-
Schultz, S. K.
-
Ponto, L. L. B.
-
Shim, H.
-
Smith, K. E.
-
Relkin, N.
-
Chaing, G.
-
Raudin, L.
-
Smith, A.
-
Fargher, K.
-
Raj, B. A.
-
Pontecorvo, M. J ...
-
Devous, M. D.
-
Rabinovici, G. D ...
-
Alexander, D. C.
-
Lyoo, C. H.
-
Evans, A. C.
-
Hansson, Oskar
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Nature Medicine
- By the university
-
University of Gothenburg
-
Lund University