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Combined Metabolic ...
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet
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- Yang, Hong (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Mayneris-Perxachs, J. (author)
- Hosp Univ Girona Doctor Josep Trueta, Girona Biomed Res Inst IDIBGI, Dept Diabet Endocrinol & Nutr, Girona 17190, Spain.;Inst Salud Carlos III, Ctr Pathophysiol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
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- Boque, N. (author)
- Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Eurecat, Reus 43204, Spain.
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- del Bas, J. M. (author)
- Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Eurecat, Reus 43204, Spain.
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- Arola, L. (author)
- Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Eurecat, Reus 43204, Spain.;Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Campus Sescelades, Tarragona 43007, Spain.
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- Yuan, Meng (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Tuerkez, H. (author)
- Ataturk Univ, Fac Med, Dept Med Biol, TR-25030 Erzurum, Turkey.
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Dept Mol & Clin Med, SE-40233 Gothenburg, Sweden.;Sahlgrens Univ Hosp, SE-40233 Gothenburg, Sweden.
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- Zhang, Cheng (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China.
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- Mardinoglu, Adil (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London WC2R 2LS, England.
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- Caimari, A. (author)
- Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Eurecat, Reus 43204, Spain.
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(creator_code:org_t)
- 2021-10-11
- 2021
- English.
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In: Biomedicines. - : MDPI AG. - 2227-9059. ; 9:10
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Although the prevalence of non-alcoholic fatty liver disease (NAFLD) continues to increase, there is no effective treatment approved for this condition. We previously showed, in high-fat diet (HFD)-fed mice, that the supplementation of combined metabolic activators (CMA), including nicotinamide riboside (NAD(+) precursor) and the potent glutathione precursors serine and N-acetyl-l-cysteine (NAC), significantly decreased fatty liver by promoting fat oxidation in mitochondria. Afterwards, in a one-day proof-of-concept human supplementation study, we observed that this CMA, including also L-carnitine tartrate (LCT), resulted in increased fatty acid oxidation and de novo glutathione synthesis. However, the underlying molecular mechanisms associated with supplementation of CMA have not been fully elucidated. Here, we demonstrated in hamsters that the chronic supplementation of this CMA (changing serine for betaine) at two doses significantly decreased hepatic steatosis. We further generated liver transcriptomics data and integrated these data using a liver-specific genome-scale metabolic model of liver tissue. We systemically determined the molecular changes after the supplementation of CMA and found that it activates mitochondria in the liver tissue by modulating global lipid, amino acid, antioxidant and folate metabolism. Our findings provide extra evidence about the beneficial effects of a treatment based on this CMA against NAFLD.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- NAFLD
- combined metabolic activators
- transcriptomics
- mitochondrial
- metabolism
- oxidative stress
- insulin-resistance
- acid oxidation
- vitamin-c
- deficiency
- expression
- protects
- disease
- obesity
- peroxisome
- Biochemistry & Molecular Biology
- Research & Experimental Medicine
- Pharmacology & Pharmacy
- NAFLD
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Yang, Hong
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Mayneris-Perxach ...
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Boque, N.
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del Bas, J. M.
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Arola, L.
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Yuan, Meng
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show more...
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Tuerkez, H.
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Uhlén, Mathias
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Borén, Jan, 1963
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Zhang, Cheng
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Mardinoglu, Adil
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Caimari, A.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Biomedicines
- By the university
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University of Gothenburg
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Royal Institute of Technology