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Blood-based biomark...
Blood-based biomarkers for Alzheimer's disease: towards clinical implementation.
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- Teunissen, Charlotte E (författare)
- Vrije Universiteit Amsterdam
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- Verberk, Inge M W (författare)
- Vrije Universiteit Amsterdam,Mayo Clinic Minnesota
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- Thijssen, Elisabeth H (författare)
- Vrije Universiteit Amsterdam
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- Vermunt, Lisa (författare)
- Vrije Universiteit Amsterdam
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital,University College London,Sahlgrenska Academy
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- van der Flier, Wiesje M (författare)
- Vrije Universiteit Amsterdam
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Mielke, Michelle M (författare)
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- Del Campo, Marta (författare)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2022
- 2022
- Engelska.
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Ingår i: The Lancet. Neurology. - 1474-4465 .- 1474-4422. ; 21:1, s. 66-77
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but recent results have shown that they could become a reality. Convincing data generated with new high-sensitivity assays have emerged with remarkable consistency across different cohorts, but also independent of the precise analytical method used. Concentrations in blood of amyloid and phosphorylated tau proteins associate with the corresponding concentrations in CSF and with amyloid-PET or tau-PET scans. Moreover, other blood-based biomarkers of neurodegeneration, such as neurofilament light chain and glial fibrillary acidic protein, appear to provide information on disease progression and potential for monitoring treatment effects. Now the question emerges of when and how we can bring these biomarkers to clinical practice. This step would pave the way for blood-based biomarkers to support the diagnosis of, and development of treatments for, Alzheimer's disease and other dementias.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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