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Prognostic Risk Ass...
Prognostic Risk Assessment and Prediction of Radiotherapy Benefit for Women with Ductal Carcinoma In Situ (DCIS) of the Breast, in a Randomized Clinical Trial (SweDCIS).
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- Wärnberg, Fredrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Karlsson, Per, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Holmberg, Erik, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Sandelin, Kerstin (author)
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Whitworth, Pat W (author)
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Savala, Jess (author)
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Barry, Todd (author)
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Leesman, Glen (author)
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Linke, Steven P (author)
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Shivers, Steven C (author)
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Vicini, Frank (author)
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Shah, Chirag (author)
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Weinmann, Sheila (author)
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Mann, Gregory Bruce (author)
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Bremer, Troy (author)
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(creator_code:org_t)
- 2021-12-03
- 2021
- English.
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In: Cancers. - : MDPI AG. - 2072-6694. ; 13:23
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
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- Prediction of radiotherapy (RT) benefit after breast-conserving surgery (BCS) for DCIS is crucial. The aim was to validate a biosignature, DCISionRT®, in the SweDCIS randomized trial. Women were randomly assigned to RT or not after BCS, between 1987 and 2000. Tumor blocks were collected, and slides were sent to PreludeDxTM for testing. In 504 women with complete data and negative margins, DCISionRT divided 52% women into Elevated (DS > 3) and 48% in Low (DS ≤ 3) Risk groups. In the Elevated Risk group, RT significantly decreased relative 10-year ipsilateral total recurrence (TotBE) and 10-year ipsilateral invasive recurrence (InvBE) rates, HR 0.32 and HR 0.24, with absolute decreases of 15.5% and 9.3%. In the Low Risk group, there were no significant risk differences observed with radiotherapy. Using a cutoff of DS > 3.0, the test was not predictive for RT benefit (p = 0.093); however, above DS > 2.8 RT benefit was greater for InvBE (interaction p = 0.038). Recurrences at 10 years without radiotherapy increased significantly per 5 DS units (TotBE HR:1.5 and InvBE HR:1.5). Continuous DS was prognostic for TotBE risk although categorical DS did not reach significance. Absolute 10-year TotBE and InvBE risks appear sufficiently different to indicate that DCISionRT can aid physicians in selecting individualized adjuvant DCIS treatment strategies. Further analyses are planned in combined cohorts to increase statistical power.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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Cancers
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- By the author/editor
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Wärnberg, Fredri ...
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Karlsson, Per, 1 ...
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Holmberg, Erik, ...
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Sandelin, Kersti ...
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Whitworth, Pat W
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Savala, Jess
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show more...
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Barry, Todd
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Leesman, Glen
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Linke, Steven P
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Shivers, Steven ...
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Vicini, Frank
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Shah, Chirag
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Weinmann, Sheila
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Mann, Gregory Br ...
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Bremer, Troy
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancers
- By the university
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University of Gothenburg
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Karolinska Institutet