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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07854naa a2201789 4500 | |
| 001 | oai:gup.ub.gu.se/311491 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3114912 URI |
| 024 | 7 | a https://doi.org/10.1007/s00428-021-03232-02 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kang, E. Y.4 aut |
| 245 | 1 0 | a MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma |
| 264 | c 2021-11-15 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a Tubo-ovarian high-grade serous carcinomas (HGSC) are highly proliferative neoplasms that generally respond well to platinum/taxane chemotherapy. We recently identified minichromosome maintenance complex component 3 (MCM3), which is involved in the initiation of DNA replication and proliferation, as a favorable prognostic marker in HGSC. Our objective was to further validate whether MCM3 mRNA expression and possibly MCM3 protein levels are associated with survival in patients with HGSC. MCM3 mRNA expression was measured using NanoString expression profiling on formalin-fixed and paraffin-embedded tissue (N = 2355 HGSC) and MCM3 protein expression was assessed by immunohistochemistry (N = 522 HGSC) and compared with Ki-67. Kaplan-Meier curves and the Cox proportional hazards model were used to estimate associations with survival. Among chemotherapy-naive HGSC, higher MCM3 mRNA expression (one standard deviation increase in the score) was associated with longer overall survival (HR = 0.87, 95% CI 0.81-0.92, p < 0.0001, N = 1840) in multivariable analysis. MCM3 mRNA expression was highest in the HGSC C5.PRO molecular subtype, although no interaction was observed between MCM3, survival and molecular subtypes. MCM3 and Ki-67 protein levels were significantly lower after exposure to neoadjuvant chemotherapy compared to chemotherapy-naive tumors: 37.0% versus 46.4% and 22.9% versus 34.2%, respectively. Among chemotherapy-naive HGSC, high MCM3 protein levels were also associated with significantly longer disease-specific survival (HR = 0.52, 95% CI 0.36-0.74, p = 0.0003, N = 392) compared to cases with low MCM3 protein levels in multivariable analysis. MCM3 immunohistochemistry is a promising surrogate marker of proliferation in HGSC. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a High-grade serous carcinoma | |
| 653 | a Proliferation | |
| 653 | a MCM3 | |
| 653 | a ovarian | |
| 653 | a expression | |
| 653 | a proteins | |
| 653 | a immunohistochemistry | |
| 653 | a predictor | |
| 653 | a patterns | |
| 653 | a cancer | |
| 653 | a ki-67 | |
| 653 | a p53 | |
| 653 | a Pathology | |
| 700 | 1 | a Millstein, J.4 aut |
| 700 | 1 | a Popovic, G.4 aut |
| 700 | 1 | a Meagher, N. S.4 aut |
| 700 | 1 | a Bolithon, A.4 aut |
| 700 | 1 | a Talhouk, A.4 aut |
| 700 | 1 | a Chiu, D. S.4 aut |
| 700 | 1 | a Anglesio, M. S.4 aut |
| 700 | 1 | a Leung, B.4 aut |
| 700 | 1 | a Tang, K.4 aut |
| 700 | 1 | a Lambie, N.4 aut |
| 700 | 1 | a Pavanello, M.4 aut |
| 700 | 1 | a Da-Anoy, A.4 aut |
| 700 | 1 | a Lambrechts, D.4 aut |
| 700 | 1 | a Loverix, L.4 aut |
| 700 | 1 | a Olbrecht, S.4 aut |
| 700 | 1 | a Bisinotto, C.4 aut |
| 700 | 1 | a Garcia-Donas, J.4 aut |
| 700 | 1 | a Ruiz-Llorente, S.4 aut |
| 700 | 1 | a Yague-Fernandez, M.4 aut |
| 700 | 1 | a Edwards, R. P.4 aut |
| 700 | 1 | a Elishaev, E.4 aut |
| 700 | 1 | a Olawaiye, A.4 aut |
| 700 | 1 | a Taylor, S.4 aut |
| 700 | 1 | a Ataseven, B.4 aut |
| 700 | 1 | a du Bois, A.4 aut |
| 700 | 1 | a Harter, P.4 aut |
| 700 | 1 | a Lester, J.4 aut |
| 700 | 1 | a Hogdall, C. K.4 aut |
| 700 | 1 | a Armasu, S. M.4 aut |
| 700 | 1 | a Huang, Y. J.4 aut |
| 700 | 1 | a Vierkant, R. A.4 aut |
| 700 | 1 | a Wang, C.4 aut |
| 700 | 1 | a Winham, S. J.4 aut |
| 700 | 1 | a Heublein, S.4 aut |
| 700 | 1 | a Kommoss, F. K. F.4 aut |
| 700 | 1 | a Cramer, D. W.4 aut |
| 700 | 1 | a Sasamoto, N.4 aut |
| 700 | 1 | a Van-Wagensveld, L.4 aut |
| 700 | 1 | a Lycke, Mariau Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xlycma |
| 700 | 1 | a Mateoiu, Constantinau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut |
| 700 | 1 | a Joseph, J.4 aut |
| 700 | 1 | a Pike, M. C.4 aut |
| 700 | 1 | a Odunsi, K.4 aut |
| 700 | 1 | a Tseng, C. C.4 aut |
| 700 | 1 | a Pearce, C. L.4 aut |
| 700 | 1 | a Bilic, S.4 aut |
| 700 | 1 | a Conrads, T. P.4 aut |
| 700 | 1 | a Hartmann, A.4 aut |
| 700 | 1 | a Hein, A.4 aut |
| 700 | 1 | a Jones, M. E.4 aut |
| 700 | 1 | a Leung, Y.4 aut |
| 700 | 1 | a Beckmann, M. W.4 aut |
| 700 | 1 | a Ruebner, M.4 aut |
| 700 | 1 | a Schoemaker, M. J.4 aut |
| 700 | 1 | a Terry, K. L.4 aut |
| 700 | 1 | a El-Bahrawy, M. A.4 aut |
| 700 | 1 | a Coulson, P.4 aut |
| 700 | 1 | a Etter, J. L.4 aut |
| 700 | 1 | a LaVigne-Mager, K.4 aut |
| 700 | 1 | a Andress, J.4 aut |
| 700 | 1 | a Grube, M.4 aut |
| 700 | 1 | a Fischer, A.4 aut |
| 700 | 1 | a Neudeck, N.4 aut |
| 700 | 1 | a Robertson, G.4 aut |
| 700 | 1 | a Farrell, R.4 aut |
| 700 | 1 | a Barlow, E.4 aut |
| 700 | 1 | a Quinn, C.4 aut |
| 700 | 1 | a Hettiaratchi, A.4 aut |
| 700 | 1 | a Casablanca, Y.4 aut |
| 700 | 1 | a Erber, R.4 aut |
| 700 | 1 | a Stewart, C. J. R.4 aut |
| 700 | 1 | a Tan, A.4 aut |
| 700 | 1 | a Yu, Y.4 aut |
| 700 | 1 | a Boros, J.4 aut |
| 700 | 1 | a Brand, A. H.4 aut |
| 700 | 1 | a Harnett, P. R.4 aut |
| 700 | 1 | a Kennedy, C. J.4 aut |
| 700 | 1 | a Nevins, N.4 aut |
| 700 | 1 | a Morgan, T.4 aut |
| 700 | 1 | a Fasching, P. A.4 aut |
| 700 | 1 | a Vergote, I.4 aut |
| 700 | 1 | a Swerdlow, A. J.4 aut |
| 700 | 1 | a Dos Reis, F. J. C.4 aut |
| 700 | 1 | a Maxwell, G. L.4 aut |
| 700 | 1 | a Neuhausen, S. L.4 aut |
| 700 | 1 | a Barquin-Garcia, A.4 aut |
| 700 | 1 | a Modugno, F.4 aut |
| 700 | 1 | a Moysich, K. B.4 aut |
| 700 | 1 | a Crowe, P. J.4 aut |
| 700 | 1 | a Hirasawa, A.4 aut |
| 700 | 1 | a Heitz, F.4 aut |
| 700 | 1 | a Karlan, B. Y.4 aut |
| 700 | 1 | a Goode, E. L.4 aut |
| 700 | 1 | a Sinn, P.4 aut |
| 700 | 1 | a Horlings, H. M.4 aut |
| 700 | 1 | a Hogdall, E.4 aut |
| 700 | 1 | a Sundfeldt, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsukar |
| 700 | 1 | a Kommoss, S.4 aut |
| 700 | 1 | a Staebler, A.4 aut |
| 700 | 1 | a Wu, A. H.4 aut |
| 700 | 1 | a Cohen, P. A.4 aut |
| 700 | 1 | a DeFazio, A.4 aut |
| 700 | 1 | a Lee, C. H.4 aut |
| 700 | 1 | a Steed, H.4 aut |
| 700 | 1 | a Le, N. D.4 aut |
| 700 | 1 | a Gayther, S. A.4 aut |
| 700 | 1 | a Lawrenson, K.4 aut |
| 700 | 1 | a Pharoah, P. D. P.4 aut |
| 700 | 1 | a Konecny, G.4 aut |
| 700 | 1 | a Cook, L. S.4 aut |
| 700 | 1 | a Ramus, S. J.4 aut |
| 700 | 1 | a Kelemen, L. E.4 aut |
| 700 | 1 | a Kobel, M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
| 773 | 0 | t Virchows Archivd : Springer Science and Business Media LLCg 480, s. 855-871q 480<855-871x 0945-6317x 1432-2307 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/311491 |
| 856 | 4 8 | u https://doi.org/10.1007/s00428-021-03232-0 |
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- Kang, E. Y.
- Millstein, J.
- Popovic, G.
- Meagher, N. S.
- Bolithon, A.
- Talhouk, A.
- visa fler...
- Chiu, D. S.
- Anglesio, M. S.
- Leung, B.
- Tang, K.
- Lambie, N.
- Pavanello, M.
- Da-Anoy, A.
- Lambrechts, D.
- Loverix, L.
- Olbrecht, S.
- Bisinotto, C.
- Garcia-Donas, J.
- Ruiz-Llorente, S ...
- Yague-Fernandez, ...
- Edwards, R. P.
- Elishaev, E.
- Olawaiye, A.
- Taylor, S.
- Ataseven, B.
- du Bois, A.
- Harter, P.
- Lester, J.
- Hogdall, C. K.
- Armasu, S. M.
- Huang, Y. J.
- Vierkant, R. A.
- Wang, C.
- Winham, S. J.
- Heublein, S.
- Kommoss, F. K. F ...
- Cramer, D. W.
- Sasamoto, N.
- Van-Wagensveld, ...
- Lycke, Maria
- Mateoiu, Constan ...
- Joseph, J.
- Pike, M. C.
- Odunsi, K.
- Tseng, C. C.
- Pearce, C. L.
- Bilic, S.
- Conrads, T. P.
- Hartmann, A.
- Hein, A.
- Jones, M. E.
- Leung, Y.
- Beckmann, M. W.
- Ruebner, M.
- Schoemaker, M. J ...
- Terry, K. L.
- El-Bahrawy, M. A ...
- Coulson, P.
- Etter, J. L.
- LaVigne-Mager, K ...
- Andress, J.
- Grube, M.
- Fischer, A.
- Neudeck, N.
- Robertson, G.
- Farrell, R.
- Barlow, E.
- Quinn, C.
- Hettiaratchi, A.
- Casablanca, Y.
- Erber, R.
- Stewart, C. J. R ...
- Tan, A.
- Yu, Y.
- Boros, J.
- Brand, A. H.
- Harnett, P. R.
- Kennedy, C. J.
- Nevins, N.
- Morgan, T.
- Fasching, P. A.
- Vergote, I.
- Swerdlow, A. J.
- Dos Reis, F. J. ...
- Maxwell, G. L.
- Neuhausen, S. L.
- Barquin-Garcia, ...
- Modugno, F.
- Moysich, K. B.
- Crowe, P. J.
- Hirasawa, A.
- Heitz, F.
- Karlan, B. Y.
- Goode, E. L.
- Sinn, P.
- Horlings, H. M.
- Hogdall, E.
- Sundfeldt, Karin ...
- Kommoss, S.
- Staebler, A.
- Wu, A. H.
- Cohen, P. A.
- DeFazio, A.
- Lee, C. H.
- Steed, H.
- Le, N. D.
- Gayther, S. A.
- Lawrenson, K.
- Pharoah, P. D. P ...
- Konecny, G.
- Cook, L. S.
- Ramus, S. J.
- Kelemen, L. E.
- Kobel, M.
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