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The effects of cont...
The effects of controlled nanotopography, machined topography and their combination on molecular activities, bone formation and biomechanical stability during osseointegration
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- Karazisis, Dimitrios, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Odontology,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden,University of Gothenburg, Sweden
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- Rasmusson, Lars, 1962 (författare)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institutionen för odontologi, sektion 1,Institute of Clinical Sciences, Department of Biomaterials,Institute of Odontology, Section 1,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Käkkliniken US,Univ Gothenburg, Sweden; Univ Gothenburg, Sweden,University of Gothenburg, Sweden; Linköping University Hospital, Sweden
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- Petronis, Sarunas (författare)
- RISE,Metodik för produktframtagning
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- Palmquist, Anders, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sweden,University of Gothenburg, Sweden
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- Shah, Furqan A. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sweden,University of Gothenburg, Sweden
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- Agheli, Hossein, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sweden,University of Gothenburg, Sweden
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- Emanuelsson, Lena, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sweden,University of Gothenburg, Sweden
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- Johansson, Anna, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sweden,University of Gothenburg, Sweden
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- Omar, Omar (författare)
- Imam Abdulrahman Bin Faisal Univ, Saudi Arabia,Imam Abdulrahman bin Faisal University, Saudi Arabia
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- Thomsen, Peter, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials,Univ Gothenburg, Sweden,University of Gothenburg, Sweden
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Acta Biomaterialia. - : Elsevier BV. - 1742-7061 .- 1878-7568. ; 136, s. 279-290
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The initial cellular and molecular activities at the bone interface of implants with controlled nanoscale topography and microscale roughness have previously been reported. However, the effects of such surface modifications on the development of osseointegration have not yet been determined. This study investigated the molecular events and the histological and biomechanical development of the bone interface in implants with nanoscale topography, microscale roughness or a combination of both. Polished and machined titanium implants with and without controlled nanopatterning (75 nm protrusions) were produced using colloidal lithography and coated with a thin titanium layer to unify the chemistry. The implants were inserted in rat tibiae and subjected to removal torque (RTQ) measurements, molecular analyses and histological analyses after 6, 21 and 28 days. The results showed that nanotopography superimposed on microrough, machined, surfaces promoted an early increase in RTQ and hence produced greater implant stability at 6 and 21 days. Two-way MANOVA revealed that the increased RTQ was influenced by microscale roughness and the combination of nanoscale and microscale topographies. Furthermore, increased bone-implant contact (BIC) was observed with the combined nanopatterned machined surface, although MANOVA results implied that the increased BIC was mainly dependent on microscale roughness. At the molecular level, the nanotopography, per se, and in synergy with microscale roughness, downregulated the expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-α). In conclusion, controlled nanotopography superimposed on microrough machined implants promoted implant stability during osseointegration. Nanoscale-driven mechanisms may involve attenuation of the inflammatory response at the titanium implant site. Statement of Significance: The role of combined implant microscale and nanotopography features for osseointegration is incompletely understood. Using colloidal lithography technique, we created an ordered nanotopography pattern superimposed on screwshaped implants with microscale topography. The midterm and late molecular, bone-implant contact and removal torque responses were analysed in vivo. Nanotopography superimposed on microrough, machined, surfaces promoted the implant stability, influenced by microscale topography and the combination of nanoscale and microscale topographies. Increased bone-implant contact was mainly dependent on microscale roughness whereas the nanotopography, per se, and in synergy with microscale roughness, attenuated the proinflammatory tumor necrosis factor alpha (TNF-α) expression. It is concluded that microscale and nanopatterns provide individual as well as synergistic effects on molecular, morphological and biomechanical implant-tissue processes in vivo.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Nyckelord
- Colloidal lithography
- Cytokines
- Gene expression
- Implant
- Microroughness
- Nanotopography
- Osseointegration
- Removal torque
- Titanium
- Colloidal lithography; Cytokines; Gene expression; Microroughness; Nanotopography; Osseointegration; Removal torque; Titanium; Implant
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Karazisis, Dimit ...
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Rasmusson, Lars, ...
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Petronis, Saruna ...
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Palmquist, Ander ...
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Shah, Furqan A.
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Agheli, Hossein, ...
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Emanuelsson, Len ...
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Johansson, Anna, ...
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Omar, Omar
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Thomsen, Peter, ...
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Linköpings universitet
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