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Transcriptomic anal...
Transcriptomic analysis reveals proinflammatory signatures associated with acute myeloid leukemia progression
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- Stratmann, Svea, 1989- (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Linda Holmfeldt
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- Yones, Sara A. (författare)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Garbulowski, Mateusz (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab
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- Sun, Jitong (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Skaftason, A. (författare)
- Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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- Mayrhofer, Markus, 1981- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,National Bioinformatics Infrastructure Sweden
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- Norgren, Nina (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology, National Bioinformatics Infrastructure Sweden; Science for Life Laboratory, Umeå University, Sweden
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- Herlin, M. K. (författare)
- Department of Clinical Medicine, Department of Pediatrics and Adolescent Medicine, Aarhus University, Denmark
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- Sundström, Christer (författare)
- Uppsala universitet,Klinisk och experimentell patologi
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- Eriksson, Anna, 1977- (författare)
- Uppsala universitet,Hematologi
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- Höglund, Martin (författare)
- Uppsala universitet,Hematologi
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- Palle, Josefine, 1964- (författare)
- Uppsala universitet,Barnonkologisk och neurologisk forskning
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- Abrahamsson, Jonas, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Jahnukainen, K. (författare)
- Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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- Munthe-Kaas, M. C. (författare)
- Norwegian Institute of Public Health, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway
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- Zeller, B. (författare)
- Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway
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- Tamm, K. P. (författare)
- Karolinska Institutet
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- Cavelier, Lucia (författare)
- Uppsala universitet,Medicinsk genetik och genomik
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- Komorowski, Jan (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,Kollegiet för avancerade studier (SCAS),Institutionen för medicinska vetenskaper,Institutionen för kvinnors och barns hälsa,The Institute of Computer Science, Polish Academy of Sciences, Warsaw, Poland; Washington National Primate Research Center, Seattle, WA, USA; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Umeå University, Umeå, Sweden; Department of Clinical Medicine and Department of Pediatrics and Adolescent Medicine, Aarhus University, Aarhus, Denmark; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Norwegian Institute of Public Health, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Department of Oncology and Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
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- Holmfeldt, Linda (författare)
- Uppsala universitet,Experimentell och klinisk onkologi,Linda Holmfeldt
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(creator_code:org_t)
- 2022-01-07
- 2022
- Engelska.
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 6:1, s. 152-164
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Abstract
Ämnesord
Stäng
- Numerous studies have been performed over the last decade to exploit the complexity of genomic and transcriptomic lesions driving the initiation of acute myeloid leukemia (AML). These studies have helped improve risk classification and treatment options. Detailed molecular characterization of longitudinal AML samples is sparse, however; meanwhile, relapse and therapy resistance represent the main challenges in AML care. To this end, we performed transcriptome-wide RNA sequencing of longitudinal diagnosis, relapse, and/or primary resistant samples from 47 adult and 23 pediatric AML patients with known mutational background. Gene expression analysis revealed the association of short event-free survival with overexpression of GLI2 and IL1R1, as well as downregulation of ST18. Moreover, CR1 downregulation and DPEP1 upregulation were associated with AML relapse both in adults and children. Finally, machine learning–based and network-based analysis identified overexpressed CD6 and downregulated INSR as highly copredictive genes depicting important relapse-associated characteristics among adult patients with AML. Our findings highlight the importance of a tumor-promoting inflammatory environment in leukemia progression, as indicated by several of the herein identified differentially expressed genes. Together, this knowledge provides the foundation for novel personalized drug targets and has the potential to maximize the benefit of current treatments to improve cure rates in AML. ß 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- CD6 antigen
- chemokine receptor CCR1
- interleukin 1 receptor type I
- vepoloxamer
- zinc finger protein GLI2
- acute myeloid leukemia
- adolescent
- adult
- aged
- Article
- cancer recurrence
- cancer resistance
- child
- controlled study
- disease course
- disease free survival
- female
- gene expression profiling
- genome
- groups by age
- human
- infant
- machine learning
- major clinical study
- male
- middle aged
- population research
- preschool child
- receptor down regulation
- RNA sequencing
- school child
- transcriptome sequencing
- treatment outcome
- young adult
- Acute myeloid leukemia
- Medicinsk vetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Stratmann, Svea, ...
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Yones, Sara A.
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Garbulowski, Mat ...
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Sun, Jitong
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Skaftason, A.
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Mayrhofer, Marku ...
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visa fler...
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Norgren, Nina
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Herlin, M. K.
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Sundström, Chris ...
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Eriksson, Anna, ...
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Höglund, Martin
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Palle, Josefine, ...
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Abrahamsson, Jon ...
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Jahnukainen, K.
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Munthe-Kaas, M. ...
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Zeller, B.
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Tamm, K. P.
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Cavelier, Lucia
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Komorowski, Jan
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Holmfeldt, Linda
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Blood Advances
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Uppsala universitet
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Karolinska Institutet