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  • Longinetti, E.Karolinska Institutet,Karolinska Institute (author)

COVID-19 clinical outcomes and DMT of MS patients and population-based controls

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-08-22
  • Wiley,2022

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/318901
  • https://gup.ub.gu.se/publication/318901URI
  • https://doi.org/10.1002/acn3.51646DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-100745URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199108URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187856URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495215URI
  • https://lup.lub.lu.se/record/24ebd2ae-c532-4a55-b5b0-a6052d555472URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:150531437URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Patient-Centered Outcomes Research Institute (PCORI) Award [MS-1511-33196]; Swedish MRC [2020-02700]; Swedish Research Council [2021-01418]; Swedish Research Council for Health, Working Life, and Welfare [2020-0115]; Knut and Alice Wallenbergs foundation [KAW 2020.0299_VC-2020-0040/VC-2021-0018]
  • Objective: To estimate risks for all-cause mortality and for severe COVID-19 in multiple sclerosis patients and across relapsing-remitting multiple sclerosis patients exposed to disease-modifying therapies. Methods: We conducted a Swedish nationwide population-based multi-register linkage cohort study and followed all multiple sclerosis patients (n = 17,692 in March 2020), individually age-, sex-, and region-matched to five population-based controls (n = 86,176 in March 2020) during March 2020-June 2021. We compared annual all-cause mortality within and across cohorts, and assessed incidence rates and relative risks for hospitalization, intensive care admission, and death due to COVID-19 in relation to disease-modifying therapy use, using Cox regression. Results: Absolute all-cause mortality among multiple sclerosis patients was higher from March to December 2020 than in previous years, but relative risks versus the population-based controls were similar to preceding years. Incidence rates of hospitalization, intensive care admission, and death due to COVID-19 remained in line with those for all-cause hospitalization, intensive care admission, and mortality. Among relapsing-remitting patients on rituximab, trends for differences in risk of hospitalization due to COVID-19 remained in the demographics-, socioeconomic status-, comorbidity-, and multiple sclerosis severity-adjusted model. Interpretation: Risks of severe COVID-19-related outcomes were increased among multiple sclerosis patients as a whole compared to population controls, but risk increases were also seen for non-COVID-19 hospitalization, intensive care admission, and mortality, and did not significantly differ during the pandemic compared to pre-pandemic years. The risk conveyed by disease-modifying therapies was smaller than previously assumed, likely as a consequence of the possibility to better control for confounders.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bower, H.Karolinska Institutet,Karolinska Institute (author)
  • McKay, K. A.Karolinska Institutet,Karolinska Institute (author)
  • Englund, S.Karolinska Institutet,Karolinska Institute (author)
  • Burman, Joachim,1974-Uppsala University,Uppsala universitet,Institutionen för medicinska vetenskaper,Experimentell neurologi(Swepub:uu)joabu293 (author)
  • Fink, K.Karolinska Institutet,Karolinska Institute (author)
  • Fogdell-Hahn, A.Karolinska Institutet,Karolinska Institute (author)
  • Gunnarsson, Martin,1973-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology, Örebro University, Örebro, Sweden,Örebro Univ, Dept Neurol, Örebro, Sweden.(Swepub:oru)mign (author)
  • Hillert, J.Karolinska Institutet,Karolinska Institute (author)
  • Langer-Gould, A.Clinical and Translational Neuroscience, Southern California Permanente Medical Group, Kaiser Permanente, Los Angeles, USA,Clinical and Translational Neuroscience, Southern California Permanente Medical Group, Kaiser Permanente, Los Angeles, United States,Kaiser Permanente, Clin & Translat Neurosci, Southern Calif Permanente Med Grp, Los Angeles, CA USA. (author)
  • Lycke, Jan,1956University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience,Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Clin Neurosci, Gothenburg, Sweden.(Swepub:gu)xlycja (author)
  • Nilsson, PetraLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)neur-pn8 (author)
  • Salzer, JonatanUmeå University,Umeå universitet,Neurovetenskaper,Umeå Univ, Dept Clin Sci, Neurosci, Umeå, Sweden.(Swepub:umu)jonser01 (author)
  • Svenningsson, A.Karolinska Institutet (author)
  • Mellergård, JohanLinköping University,Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.(Swepub:liu)johme15 (author)
  • Olsson, T.Karolinska Institutet,Karolinska Institute (author)
  • Piehl, F.Karolinska Institute (author)
  • Frisell, T.Karolinska Institutet,Karolinska Institute (author)
  • Karolinska InstitutetKarolinska Institute (creator_code:org_t)

Related titles

  • In:Annals of Clinical and Translational Neurology: Wiley9:9, s. 1449-14582328-9503

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