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Worsening of Renal ...
Worsening of Renal Function Among Hospitalized Patients With Acute Heart Failure: Phenotyping, Outcomes, and Predictors.
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He, Xin (författare)
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Dong, Bin (författare)
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Liang, Weihao (författare)
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Xue, Ruicong (författare)
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Zhao, Jingjing (författare)
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Wu, Zexuan (författare)
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Wei, Fangfei (författare)
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Huang, Peisen (författare)
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Zhu, Wengen (författare)
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He, Jiangui (författare)
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Dong, Yugang (författare)
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- Fu, Michael, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Liu, Chen (författare)
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(creator_code:org_t)
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- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Mayo Clinic proceedings. - : Elsevier BV. - 1942-5546 .- 0025-6196. ; 97:9, s. 1619-1630
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To define clinical phenotyping and its associated outcome of worsening of renal function (WRF) in hospitalized acute heart failure (AHF) patients.Latent class analysis was performed in 113 AHF patients who developed WRF within 72 hours in the DOSE (Diuretic Optimization Strategies Evaluation) trial (from March 2008 to November 2009) and ROSE-AHF (Renal Optimization Strategies Evaluation in Acute Heart Failure) trial (from September 2010 to March 2013) to identify potential WRF phenotypes. Clinical characteristics and outcome (in-hospital and post-discharge) were compared between different phenotypes.Two WRF phenotypes were identified by latent class analysis, which we named WRF minimally responsive to diuretics (WRF-MRD) and WRF responsive to diuretics (WRF-RD). Among the population, 58 (9.5%) developed WRF-MRD and 55 (9.0%) developed WRF-RD. Patients with WRF-MRD had more comorbidities than WRF-RD. In WRF-MRD, there were an early increase in serum creatinine, a smaller amount of net fluid loss and weight loss, and a higher rate of worsening or persistent heart failure over 72 hours. In contrast, for those with WRF-RD, they had faster in-hospital net fluid loss and weight loss and a better 60-day survival after discharge even compared with patients without WRF (P=.004). Furthermore, baseline chronic obstructive pulmonary disease, diabetes, and cystatin C were independent predictors of WRF-MRD, whereas serum hemoglobin and sodium predicted WRF-RD.Among hospitalized AHF patients, we identified two phenotypes of WRF with distinct response to heart failure treatment, predictors, and short-term prognosis after discharge. The results could help early differentiation of WRF phenotypes in clinical practice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Acute Disease
- Aftercare
- Clinical Trials as Topic
- Creatinine
- Diuretics
- therapeutic use
- Glomerular Filtration Rate
- physiology
- Heart Failure
- Humans
- Kidney
- physiology
- Patient Discharge
- Prognosis
- Weight Loss
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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He, Xin
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Dong, Bin
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Liang, Weihao
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Xue, Ruicong
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Zhao, Jingjing
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Wu, Zexuan
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visa fler...
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Wei, Fangfei
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Huang, Peisen
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Zhu, Wengen
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He, Jiangui
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Dong, Yugang
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Fu, Michael, 196 ...
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Liu, Chen
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Mayo Clinic proc ...
- Av lärosätet
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Göteborgs universitet