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Using a Clinicopath...
Using a Clinicopathologic and Gene Expression (CP-GEP) Model to Identify Stage I-II Melanoma Patients at Risk of Disease Relapse.
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Mulder, Evalyn E A P (author)
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- Johansson, Iva, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Grünhagen, Dirk J (author)
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Tempel, Dennie (author)
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Rentroia-Pacheco, Barbara (author)
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Dwarkasing, Jvalini T (author)
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Verver, Daniëlle (author)
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Mooyaart, Antien L (author)
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van der Veldt, Astrid A M (author)
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Wakkee, Marlies (author)
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Nijsten, Tamar E C (author)
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Verhoef, Cornelis (author)
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Mattsson, Jan (author)
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- Ny, Lars, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Hollestein, Loes M (author)
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- Olofsson Bagge, Roger, 1978 (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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(creator_code:org_t)
- 2022-06-09
- 2022
- English.
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In: Cancers. - : MDPI AG. - 2072-6694. ; 14:12
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Abstract
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- The current standard of care for patients without sentinel node (SN) metastasis (i.e., stage I-II melanoma) is watchful waiting, while >40% of patients with stage IB-IIC will eventually present with disease recurrence or die as a result of melanoma. With the prospect of adjuvant therapeutic options for patients with a negative SN, we assessed the performance of a clinicopathologic and gene expression (CP-GEP) model, a model originally developed to predict SN metastasis, to identify patients with stage I-II melanoma at risk of disease relapse.This study included patients with cutaneous melanoma ≥18 years of age with a negative SN between October 2006 and December 2017 at the Sahlgrenska University Hospital (Sweden) and Erasmus MC Cancer Institute (the Netherlands). According to the CP-GEP model, which can be applied to the primary melanoma tissue, the patients were stratified into high or low risk of recurrence. The primary aim was to assess the 5-year recurrence-free survival (RFS) of low- and high-risk CP-GEP. A secondary aim was to compare the CP-GEP model with the EORTC nomogram, a model based on clinicopathological variables only.In total, 535 patients (stage I-II) were included. CP-GEP stratification among these patients resulted in a 5-year RFS of 92.9% (95% confidence interval (CI): 86.4-96.4) in CP-GEP low-risk patients (n = 122) versus 80.7% (95%CI: 76.3-84.3) in CP-GEP high-risk patients (n = 413; hazard ratio 2.93 (95%CI: 1.41-6.09), p < 0.004). According to the EORTC nomogram, 25% of the patients were classified as having a 'low risk' of recurrence (96.8% 5-year RFS (95%CI 91.6-98.8), n = 130), 49% as 'intermediate risk' (88.4% 5-year RFS (95%CI 83.6-91.8), n = 261), and 26% as 'high risk' (61.1% 5-year RFS (95%CI 51.9-69.1), n = 137).In these two independent European cohorts, the CP-GEP model was able to stratify patients with stage I-II melanoma into two groups differentiated by RFS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Mulder, Evalyn E ...
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Johansson, Iva, ...
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Grünhagen, Dirk ...
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Tempel, Dennie
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Rentroia-Pacheco ...
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Dwarkasing, Jval ...
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show more...
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Verver, Daniëlle
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Mooyaart, Antien ...
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van der Veldt, A ...
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Wakkee, Marlies
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Nijsten, Tamar E ...
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Verhoef, Corneli ...
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Mattsson, Jan
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Ny, Lars, 1967
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Hollestein, Loes ...
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Olofsson Bagge, ...
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- MEDICAL AND HEALTH SCIENCES
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Cancers
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University of Gothenburg