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Genetic Diversity a...
Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives
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Manuylov, V. (author)
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Chulanov, V. (author)
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Bezuglova, L. (author)
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Chub, E. (author)
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Karlsen, A. (author)
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Kyuregyan, K. (author)
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Ostankova, Y. (author)
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Semenov, A. (author)
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Osipova, L. (author)
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Tallo, T. (author)
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Netesova, I. (author)
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Tkachuk, A. (author)
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Gushchin, V. (author)
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Netesov, S. (author)
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Magnius, L. O. (author)
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- Norder, Helene (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- 2022-11-07
- 2022
- English.
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In: Viruses. - : MDPI AG. - 1999-4915. ; 14:11
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Abstract
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- A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%) and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- aboriginal population
- genotypes
- HBsAg subtypes
- hepatitis B virus
- molecular epidemiology
- Siberia
- Siberian natives
- subgenotypes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Manuylov, V.
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Chulanov, V.
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Bezuglova, L.
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Chub, E.
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Karlsen, A.
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Kyuregyan, K.
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show more...
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Ostankova, Y.
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Semenov, A.
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Osipova, L.
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Tallo, T.
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Netesova, I.
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Tkachuk, A.
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Gushchin, V.
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Netesov, S.
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Magnius, L. O.
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Norder, Helene
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Viruses
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University of Gothenburg