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Association Between...
Association Between Serum Albumin and Outcomes in Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial.
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Feng, Kent Y (författare)
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Ambrosy, Andrew P (författare)
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Zhou, Zhipeng (författare)
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Li, Ditian (författare)
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Kong, Jeremy (författare)
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Zaroff, Jonathan G (författare)
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Mishell, Jacob M (författare)
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Ku, Ivy A (författare)
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Scotti, Andrea (författare)
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Coisne, Augustin (författare)
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- Redfors, Björn (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Mack, Michael J (författare)
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Abraham, William T (författare)
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Lindenfeld, JoAnn (författare)
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Stone, Gregg W (författare)
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(creator_code:org_t)
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- 2023-03-07
- 2023
- Engelska.
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Ingår i: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842.
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Low serum albumin levels are associated with poor prognosis in numerous chronic disease states but the relationship between albumin and outcomes in patients with heart failure (HF) and secondary mitral regurgitation (SMR) has not been described.The randomized COAPT trial evaluated the safety and effectiveness of transcatheter edge-to-edge repair (TEER) with the MitraClip plus guideline-directed medical therapy (GDMT) versus GDMT alone in patients with symptomatic HF and moderate-to-severe or severe SMR. Baseline serum albumin levels were measured at enrollment. Among 614 patients enrolled in COAPT, 559 (91.0%) had available baseline serum albumin levels (median 4.0 g/dL, IQR 3.7-4.2 g/dL). Patients with albumin <4.0 g/dL compared with ≥4.0 g/dL were older and more likely to have ischemic cardiomyopathy and a hospitalization within the year prior to enrollment. After multivariable adjustment, patients with albumin <4.0 g/dL had higher 4-year rates of all-cause death (63.7% vs. 47.6%; adjusted HR 1.34, 95% CI 1.02-1.74; p=0.032), but there were no significant differences in heart failure hospitalizations (HFH) or all-cause hospitalizations according to baseline serum albumin level. The relative effectiveness of TEER plus GDMT versus GDMT alone was consistent in patients with low and high albumin levels (Pinteraction = 0.19 and 0.35 for death and HFH, respectively).Low baseline serum albumin levels were independently associated with reduced 4-year survival in patients with HF and severe SMR enrolled in the COAPT trial, but not with HFH. Patients treated with TEER derived similarly robust reductions in both death and HFH regardless of baseline albumin level. This article is protected by copyright. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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- Av författaren/redakt...
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Feng, Kent Y
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Ambrosy, Andrew ...
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Zhou, Zhipeng
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Li, Ditian
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Kong, Jeremy
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Zaroff, Jonathan ...
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visa fler...
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Mishell, Jacob M
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Ku, Ivy A
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Scotti, Andrea
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Coisne, Augustin
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Redfors, Björn
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Mack, Michael J
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Abraham, William ...
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Lindenfeld, JoAn ...
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Stone, Gregg W
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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European journal ...
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Göteborgs universitet