Sökning: onr:"swepub:oai:gup.ub.gu.se/326213" >
Molecules of senesc...
Molecules of senescent glial cells differentiate Alzheimer's disease from ageing
-
Dai, L. B. (författare)
-
Gao, F. (författare)
-
Wang, Q. (författare)
-
visa fler...
-
Lv, X. Y. (författare)
-
Cheng, Z. Z. (författare)
-
Wu, Y. (författare)
-
Chai, X. L. (författare)
-
- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Levey, A. I. (författare)
-
Shi, J. (författare)
-
Shen, Y. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska.
-
Ingår i: Journal of Neurology Neurosurgery and Psychiatry. - 0022-3050. ; 94:7, s. 550-9
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Ageing is a major risk factor for Alzheimer's disease (AD), which is accompanied by cellular senescence and thousands of transcriptional changes in the brain. Objectives To identify the biomarkers in the cerebrospinal fluid (CSF) that could help differentiate healthy ageing from neurodegenerative processes. Methods Cellular senescence and ageing-related biomarkers were assessed in primary astrocytes and postmortem brains by immunoblotting and immunohistochemistry. The biomarkers were measured in CSF samples from the China Ageing and Neurodegenerative Disorder Initiative cohort using Elisa and the multiplex Luminex platform. Results The cyclin-dependent kinase inhibitors p16/ p21-positive senescent cells in human postmortem brains were predominantly astrocytes and oligodendrocyte lineage cells, which accumulated in AD brains. CCL2, YKL-40, HGF, MIF, S100B, TSP2, LCN2 and serpinA3 are biomarkers closely related to human glial senescence. Moreover, we discovered that most of these molecules, which were upregulated in senescent glial cells, were significantly elevated in the AD brain. Notably, CSF YKL-40 (beta=0.5412, p<0.0001) levels were markedly elevated with age in healthy older individuals, whereas HGF (beta=0.2732, p=0.0001), MIF (beta=0.33714, p=0.0017) and TSP2 (beta=0.1996, p=0.0297) levels were more susceptible to age in older individuals with AD pathology. We revealed that YKL-40, TSP2 and serpinA3 were useful biomarkers for discriminating patients with AD from CN individuals and non-AD patients. Discussion Our findings demonstrated the different patterns of CSF biomarkers related to senescent glial cells between normal ageing and AD, implicating these biomarkers could identify the road node in healthy path off to neurodegeneration and improve the accuracy of clinical AD diagnosis, which would help promote healthy ageing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- alzheimer's disease
- neuropathology
- reactive astrocytes
- brain
- alpha-1-antichymotrypsin
- expression
- biomarkers
- dementia
- protein
- association
- correlate
- ykl-40
- Neurosciences & Neurology
- Psychiatry
- Surgery
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Dai, L. B.
-
Gao, F.
-
Wang, Q.
-
Lv, X. Y.
-
Cheng, Z. Z.
-
Wu, Y.
-
visa fler...
-
Chai, X. L.
-
Zetterberg, Henr ...
-
Blennow, Kaj, 19 ...
-
Levey, A. I.
-
Shi, J.
-
Shen, Y.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Journal of Neuro ...
- Av lärosätet
-
Göteborgs universitet