Sökning: onr:"swepub:oai:gup.ub.gu.se/326367" > Transcatheter Mitra...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04983naa a2200829 4500 | |
001 | oai:gup.ub.gu.se/326367 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3263672 URI |
024 | 7 | a https://doi.org/10.1161/CIRCINTERVENTIONS.123.0130452 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ludwig, Sebastian4 aut |
245 | 1 0 | a Transcatheter Mitral Valve Replacement versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score-Matched Comparison. |
264 | 1 | c 2023 |
520 | a Background: Transcatheter mitral valve replacement (TMVR) is an emerging therapeutic alternative for patients with secondary mitral regurgitation (MR). Outcomes of TMVR versus guideline-directed medical therapy (GDMT) have not been investigated for this population. This study aimed to compare clinical outcomes of patients with secondary MR undergoing TMVR versus GDMT alone. Methods: The CHOICE-MI registry included patients with MR undergoing TMVR using dedicated devices. Patients with MR etiologies other than secondary MR were excluded. Patients treated with GDMT alone were derived from the control arm of the COAPT trial. We compared outcomes between the TMVR and GDMT groups, using propensity score (PS)-matching to adjust for baseline differences. Results: After PS-matching, 97 patient pairs undergoing TMVR (72.9±8.7 years, 60.8% male, transapical access 91.8%) versus GDMT (73.1±11.0 years, 59.8% male) were compared. At 1 and 2 years, residual MR was ≤1+ in all patients of the TMVR group compared to 6.9% and 7.7%, respectively, in those receiving GDMT alone (both p<0.001). The 2-year rate of HF hospitalization was significantly lower in the TMVR group (32.8% vs. 54.4%, HR 0.59, 95% CI 0.35-0.99; p=0.04). Among survivors, a higher proportion of patients were in NYHA functional class I or II in the TMVR group at 1 year (78.2% vs. 59.7%, p=0.03) and at 2 years (77.8% vs. 53.2%, p=0.09). Two-year mortality was similar in the two groups (TMVR vs. GDMT, 36.8% vs. 40.8%, HR 1.01, 95% CI 0.62-1.64; p=0.98). Conclusions: In this observational comparison, over 2-year follow-up, TMVR using mostly transapical devices in patients with secondary MR was associated with significant reduction of MR, symptomatic improvement, less frequent hospitalizations for HF and similar mortality compared with GDMT. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Conradi, Lenard4 aut |
700 | 1 | a Cohen, David J4 aut |
700 | 1 | a Coisne, Augustin4 aut |
700 | 1 | a Scotti, Andrea4 aut |
700 | 1 | a Abraham, William T4 aut |
700 | 1 | a Ben Ali, Walid4 aut |
700 | 1 | a Zhou, Zhipeng4 aut |
700 | 1 | a Li, Yanru4 aut |
700 | 1 | a Kar, Saibal4 aut |
700 | 1 | a Duncan, Alison4 aut |
700 | 1 | a Lim, D Scott4 aut |
700 | 1 | a Adamo, Marianna4 aut |
700 | 1 | a Redfors, Björnu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xredbj |
700 | 1 | a Muller, David W M4 aut |
700 | 1 | a Webb, John G4 aut |
700 | 1 | a Petronio, Anna Sonia4 aut |
700 | 1 | a Ruge, Hendrik4 aut |
700 | 1 | a Nickenig, Georg4 aut |
700 | 1 | a Sondergaard, Lars4 aut |
700 | 1 | a Adam, Matti4 aut |
700 | 1 | a Regazzoli, Damiano4 aut |
700 | 1 | a Garatti, Andrea4 aut |
700 | 1 | a Schmidt, Tobias4 aut |
700 | 1 | a Andreas, Martin4 aut |
700 | 1 | a Dahle, Gry4 aut |
700 | 1 | a Walther, Thomas4 aut |
700 | 1 | a Kempfert, Joerg4 aut |
700 | 1 | a Tang, Gilbert Hl4 aut |
700 | 1 | a Redwood, Simon R4 aut |
700 | 1 | a Taramasso, Maurizio4 aut |
700 | 1 | a Praz, Fabien4 aut |
700 | 1 | a Fam, Neil P4 aut |
700 | 1 | a Dumonteil, Nicolas4 aut |
700 | 1 | a Obadia, Jean-François4 aut |
700 | 1 | a von Bardeleben, Ralph Stephan4 aut |
700 | 1 | a Rudolph, Tanja Katharina4 aut |
700 | 1 | a Reardon, Michael J4 aut |
700 | 1 | a Metra, Marco4 aut |
700 | 1 | a Denti, Paolo4 aut |
700 | 1 | a Mack, Michael J4 aut |
700 | 1 | a Hausleiter, Jörg4 aut |
700 | 1 | a Asch, Federico M4 aut |
700 | 1 | a Latib, Azeem4 aut |
700 | 1 | a Lindenfeld, JoAnn4 aut |
700 | 1 | a Modine, Thomas4 aut |
700 | 1 | a Stone, Gregg W4 aut |
700 | 1 | a Granada, Juan F4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t Circulation. Cardiovascular interventionsg 16:6q 16:6x 1941-7632 |
856 | 4 8 | u https://gup.ub.gu.se/publication/326367 |
856 | 4 8 | u https://doi.org/10.1161/CIRCINTERVENTIONS.123.013045 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy