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Blood beta-synuclei...
Blood beta-synuclein is related to amyloid PET positivity in memory clinic patients
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Oeckl, P. (author)
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- Bluma, M. (author)
- Karolinska Institutet
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- Bucci, M. (author)
- Karolinska Institutet
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Halbgebauer, S. (author)
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- Chiotis, K. (author)
- Karolinska Institutet
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- Sandebring-Matton, A. (author)
- Karolinska Institutet
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- Ashton, Nicholas J. (author)
- Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Di Molfetta, Guglielmo, 1995 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Grötschel, Lana, 1993 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Kivipelto, M. (author)
- Karolinska Institutet
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Savitcheva, I. (author)
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- Nordberg, A. (author)
- Karolinska Institutet
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Otto, M. (author)
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Alzheimers & Dementia. - 1552-5260. ; 19:11, s. 4896-4907
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Abstract
Subject headings
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- Introduction: beta-synuclein is an emerging blood biomarker to study synaptic degeneration in Alzheimert's disease (AD), but its relation to amyloid-beta (A beta) pathology is unclear. Methods: We investigated the association of plasma beta-synuclein levels with ([18F])flutemetamol positron emission tomography (PET) in patients with AD dementia (n = 51), mild cognitive impairment (MCI-A beta+ n = 18, MCI-A beta-n = 30), non-AD dementias (n = 22), and non-demented controls (n = 5). Results: Plasma beta-synuclein levels were higher in A beta+(AD dementia, MCI-A beta+) than in A beta-subjects (non-AD dementias, MCI-A beta-) with good discrimination of A beta+ from A beta-subjects and prediction of A beta status in MCI individuals. A positive correlation between plasma beta-synuclein and A beta PET was observed in multiple cortical regions across all lobes. Discussion: Plasma beta-synuclein demonstrated discriminative properties for A beta PET positive and negative subjects. Our data underline that beta-synuclein is not a direct marker of A beta pathology and suggest different longitudinal dynamics of synaptic degeneration versus amyloid deposition across the AD continuum.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid beta PET
- blood biomarker
- synaptic
- degeneration
- beta-synuclein
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Oeckl, P.
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Bluma, M.
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Bucci, M.
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Halbgebauer, S.
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Chiotis, K.
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Sandebring-Matto ...
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show more...
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Ashton, Nicholas ...
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Di Molfetta, Gug ...
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Grötschel, Lana, ...
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Kivipelto, M.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Savitcheva, I.
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Nordberg, A.
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Otto, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimers & Dem ...
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Alzheimer's & de ...
- By the university
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University of Gothenburg
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Karolinska Institutet