onr:"swepub:oai:gup.ub.gu.se/330378"
Search: onr:"swepub:oai:gup.ub.gu.se/330378" > Calmodulin regulate...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Eisele-Bürger, Anna MariaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology,Institutionen för molekylära vetenskaper,Department of Molecular Sciences,University of Gothenburg (author)
Calmodulin regulates protease versus co-chaperone activity of a metacaspase
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2023
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/330378
- https://gup.ub.gu.se/publication/330378URI
- https://doi.org/10.1016/j.celrep.2023.113372DOI
- https://res.slu.se/id/publ/127490URI
Supplementary language notes
- Language:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Metacaspases are ancestral homologs of caspases that can either promote cell death or confer cytoprotection. Furthermore, yeast (Saccharomyces cerevisiae) metacaspase Mca1 possesses dual biochemical activity: proteolytic activity causing cell death and cytoprotective, co-chaperone-like activity retarding replicative aging. The molecular mechanism favoring one activity of Mca1 over another remains elusive. Here, we show that this mechanism involves calmodulin binding to the N-terminal pro-domain of Mca1, which prevents its proteolytic activation and promotes co-chaperone-like activity, thus switching from pro-cell death to anti-aging function. The longevity-promoting effect of Mca1 requires the Hsp40 co-chaperone Sis1, which is necessary for Mca1 recruitment to protein aggregates and their clearance. In contrast, proteolytically active Mca1 cleaves Sis1 both in vitro and in vivo, further clarifying molecular mechanism behind a dual role of Mca1 as a cell-death protease versus gerontogene.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- aging
- calmodulin
- chaperone
- Cmd1
- CP: Cell biology
- longevity
- Mca1
- metacaspase
- protein quality control
- proteostasis
- Sis1
Added entries (persons, corporate bodies, meetings, titles ...)
- Eisele, FrederikGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institutionen för kemi och molekylärbiologi,Institute of Biomedicine, Department of Microbiology and Immunology,Department of Chemistry and Molecular Biology(Swepub:gu)xeisfr (author)
- Hill, Sandra Malmgren,1987Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xmalms (author)
- Hao, XinxinGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xxinha (author)
- Schneider, KaraGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xschne (author)
- Imamoglu, Rahmi (author)
- Balchin, David (author)
- Liu, Beidong,1972Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xbeili (author)
- Hartl, F. Ulrich (author)
- Bozhkov, PeterSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för molekylära vetenskaper,Department of Molecular Sciences(Swepub:slu)49725 (author)
- Nyström, Thomas,1960Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology(Swepub:gu)xnysth (author)
- Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)
- Sveriges lantbruksuniversitet
Related titles
- In:Cell Reports42:112211-1247
Internet link
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Eisele-Bürger, A ...
- Eisele, Frederik
- Hill, Sandra Mal ...
- Hao, Xinxin
- Schneider, Kara
- Imamoglu, Rahmi
- show more...
- Balchin, David
- Liu, Beidong, 19 ...
- Hartl, F. Ulrich
- Bozhkov, Peter
- Nyström, Thomas, ...
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Cell Biology
- Articles in the publication
- Cell Reports
- By the university
- University of Gothenburg
- Swedish University of Agricultural Sciences
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
