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Association of plas...
Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative
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Sanchez, Erlan (author)
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Wilkinson, Tim (author)
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Coughlan, Gillian (author)
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Mirza, Saira (author)
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Baril, Andrée Ann (author)
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Ramirez, Joel (author)
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Binns, Malcolm A. (author)
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Black, Sandra E. (author)
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Borrie, Michael (author)
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Dilliott, Allison A. (author)
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Dixon, Roger A. (author)
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Dowlatshahi, Dar (author)
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Farhan, Sali (author)
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Finger, Elizabeth (author)
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Fischer, Corinne E. (author)
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Frank, Andrew (author)
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Freedman, Morris (author)
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Goncalves, Rafaella A. (author)
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Grimes, David A. (author)
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Hassan, Ayman (author)
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Hegele, Robert A. (author)
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Kumar, Sanjeev (author)
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Lang, Anthony E. (author)
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Marras, Connie (author)
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McLaughlin, Paula M. (author)
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Orange, Joseph B. (author)
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Pasternak, Stephen H. (author)
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Pollock, Bruce G. (author)
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Rajji, Tarek K. (author)
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Roberts, Angela C. (author)
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Robinson, John F. (author)
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Rogaeva, Ekaterina (author)
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Sahlas, Demetrios J. (author)
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Saposnik, Gustavo (author)
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Strong, Michael J. (author)
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Swartz, Richard H. (author)
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Tang-Wai, David F. (author)
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Tartaglia, Maria Carmela (author)
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Troyer, Angela K. (author)
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- Kvartsberg, Hlin, 1987 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Munoz, Douglas P. (author)
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Masellis, Mario (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Alzheimer's and Dementia. - 1552-5260 .- 1552-5279. ; 20:3, s. 1753-1770
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- INTRODUCTION: We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases. METHODS: Glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (Aβ)42/40 were measured using ultra-sensitive Simoa immunoassays in 44 healthy controls and 480 participants diagnosed with Alzheimer's disease/mild cognitive impairment (AD/MCI), Parkinson's disease (PD), frontotemporal dementia (FTD) spectrum disorders, or cerebrovascular disease (CVD). RESULTS: GFAP, NfL, and/or p-tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p-tau181 were highly predictive across diseases, p-tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for Aβ42/40. DISCUSSION: GFAP, NfL, and p-tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- activities of daily living
- amyloid
- amyloid beta
- blood
- blood-based
- cognition
- dementia
- glial fibrillary acidic protein
- longitudinal
- neurofilament light chain
- neuropsychiatric
- phosphorylated tau
- protein
- tau
- vascular
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sanchez, Erlan
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Wilkinson, Tim
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Coughlan, Gillia ...
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Mirza, Saira
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Baril, Andrée An ...
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Ramirez, Joel
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show more...
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Binns, Malcolm A ...
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Black, Sandra E.
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Borrie, Michael
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Dilliott, Alliso ...
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Dixon, Roger A.
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Dowlatshahi, Dar
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Farhan, Sali
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Finger, Elizabet ...
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Fischer, Corinne ...
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Frank, Andrew
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Freedman, Morris
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Goncalves, Rafae ...
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Grimes, David A.
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Hassan, Ayman
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Hegele, Robert A ...
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Kumar, Sanjeev
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Lang, Anthony E.
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Marras, Connie
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McLaughlin, Paul ...
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Orange, Joseph B ...
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Pasternak, Steph ...
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Pollock, Bruce G ...
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Rajji, Tarek K.
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Roberts, Angela ...
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Robinson, John F ...
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Rogaeva, Ekateri ...
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Sahlas, Demetrio ...
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Saposnik, Gustav ...
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Strong, Michael ...
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Swartz, Richard ...
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Tang-Wai, David ...
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Tartaglia, Maria ...
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Troyer, Angela K ...
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Kvartsberg, Hlin ...
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Zetterberg, Henr ...
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Munoz, Douglas P ...
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Masellis, Mario
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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University of Gothenburg