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Population-based Or...
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Bratt, Ola,1963Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
(författare)
Population-based Organised Prostate Cancer Testing: Results from the First Invitation of 50-year-old Men
- Artikel/kapitelEngelska2024
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LIBRIS-ID:oai:gup.ub.gu.se/332570
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https://gup.ub.gu.se/publication/332570URI
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https://doi.org/10.1016/j.eururo.2023.11.013DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:238042646URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:155440979URI
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Background: The European Union recently recommended evaluation of the feasibility of organised prostate cancer screening. In Sweden, regional population-based organised prostate cancer testing (OPT) programmes were introduced in 2020. Objective: To describe initial participation rates and diagnostic outcomes. Design, setting, and participants: The three most populated Swedish regions invited all men aged 50 yr to OPT by a letter in 2020–2022. Men with prostate-specific antigen (PSA) ≥3 ng/ml were referred for prostate magnetic resonance imaging (MRI). PSA assays differed across regions. Men with Prostate Imaging Reporting and Data System (PI-RADS) 1–3 and PSA density ≥0.15 ng/ml/cm3 or PI-RADS 4–5 were referred for a biopsy. Data were obtained from the Swedish Register for Organised Prostate Cancer Testing. Outcome measurements and statistical analysis: Overall and regional participation rates, PSA distributions, PI-RADS score distributions, cancer detection, and treatment were evaluated. Results and limitations: A total of 23 855 (35%) of 68 060 invited men participated; 696 (2.9%) had PSA ≥3 ng/ml, and of them, 306 (44%) had a biopsy indication and 221 (32%) had a biopsy. On biopsy, 93 (42%) had Gleason grade group ≥2 (0.39% of PSA-tested men) and 44 (20%) Gleason grade group 1 cancer. Most men with cancer had treatment with curative intent (70%) or were under active surveillance (28%). Across regions, proportions of men with PSA ≥3 ng/ml ranged from 2.3% to 4.0%, and those with PI-RADS score 4–5 ranged from 12% to 21%. A limitation is that results are applicable only to first testing of men in their early 50s. Conclusions: The OPT programmes are feasible with good compliance to the diagnostic pathway. The use of MRI and PSA density avoided a biopsy for over half of the men with PSA ≥3 ng/ml. Inter-regional differences in diagnostic outcomes show a need for standardisation of the diagnostic pathway's components. Patient summary: We report the diagnostic outcomes of inviting 68 000 50-yr-old men to organised prostate cancer testing.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Godtman, Rebecka Arnsrud,1981Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xgodre
(författare)
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Jiborn, Thomas
(författare)
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Wallström, JonasGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
(författare)
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Akre, OlofKarolinska Institutet
(författare)
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Carlsson, StefanKarolinska Institutet
(författare)
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Nordström, TobiasKarolinska Institutet
(författare)
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Thimansson, Erik
(författare)
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Alterbeck, Max
(författare)
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Zackrisson, Sophia
(författare)
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Hugosson, Jonas,1955Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology(Swepub:gu)xhugjo
(författare)
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Bjartell, Anders
(författare)
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Lantz, AnnaKarolinska Institutet
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för urologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Urology85:3, s. 207-2140302-28381873-7560
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Bratt, Ola, 1963
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Godtman, Rebecka ...
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Jiborn, Thomas
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Wallström, Jonas
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Akre, Olof
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Carlsson, Stefan
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visa fler...
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Nordström, Tobia ...
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Thimansson, Erik
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Alterbeck, Max
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Zackrisson, Soph ...
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Hugosson, Jonas, ...
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Bjartell, Anders
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Lantz, Anna
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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European Urology
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Göteborgs universitet
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Karolinska Institutet