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Baseline Serum Pros...
Baseline Serum Prostate-specific Antigen Value Predicts the Risk of Subsequent Prostate Cancer Death-Results from the Norwegian Prostate Cancer Consortium.
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- Bjerner, Johan (författare)
- Fürst Medical Laboratories
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- Bratt, Ola, 1963 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Aas, Kirsti (författare)
- Oslo university hospital
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- Albertsen, Peter C (författare)
- University of Connecticut
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- Fosså, Sophie D (författare)
- Oslo university hospital
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- Kvåle, Rune (författare)
- Haukeland University Hospital
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- Lilja, Hans (författare)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Clinical Chemistry, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Memorial Sloan-Kettering Cancer Center,Skåne University Hospital
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- Müller, Christoph (författare)
- Sørlandet Hospital
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- Müller, Stig (författare)
- Akershus University Hospital
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Stensvold, Andreas (författare)
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- Thomas, Owen (författare)
- Akershus University Hospital
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- Røe, Oluf D (författare)
- Norwegian University of Science and Technology
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- Vickers, Andrew (författare)
- Memorial Sloan-Kettering Cancer Center
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Walz, Jochen (författare)
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- Carlsson, Sigrid V (författare)
- Memorial Sloan-Kettering Cancer Center,Sahlgrenska Academy
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- Oldenburg, Jan (författare)
- University of Oslo,Akershus University Hospital
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: European Urology. - 0302-2838. ; 86:1, s. 20-26
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Prostate-specific antigen (PSA) levels in midlife are strongly associated with the long-term risk of lethal prostate cancer in cohorts not subject to screening. This is the first study evaluating the association between PSA levels drawn as part of routine medical care in the Norwegian population and prostate cancer incidence and mortality.To determine the association between midlife PSA levels <4.0 ng/ml, drawn as part of routine medical care, and long-term risk of prostate cancer death.The Norwegian Prostate Cancer Consortium collected >8 million PSA results from >1 million Norwegian males ≥40 yr of age. We studied 176099 men (predefined age strata: 40-54 and 55-69 yr) without a prior prostate cancer diagnosis who had a nonelevated baseline PSA level (<4.0 ng/ml) between January 1, 1995 and December 31, 2005.Baseline PSA.We assessed the 16-yr risk of prostate cancer mortality. We calculated the discrimination (C-index) between predefined PSA strata (<0.5, 0.5-0.9, 1.0-1.9, 2.0-2.9, and 3.0-3.9 ng/ml) and subsequent prostate cancer death. Survival curves were plotted using the Kaplan-Meier method.The median follow-up time of men who did not get prostate cancer was 17.9 yr. Overall, 84% of men had a baseline PSA level of <2.0 ng/ml and 1346 men died from prostate cancer, with 712 deaths (53%) occurring in the 16% of men with the highest baseline PSA of 2.0-3.9 ng/ml. Baseline PSA levels were associated with prostate cancer mortality (C-index 0.72 for both age groups, 40-54 and 55-69 yr). The fact that the reason for any given PSA measurement remains unknown represents a limitation.We replicated prior studies that baseline PSA at age 40-69 yr can be used to stratify a man's risk of dying from prostate cancer within the next 15-20 yr.A prostate-specific antigen level obtained as part of routine medical care is strongly associated with a man's risk of dying from prostate cancer in the next two decades.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Prostate cancer
- Prostate-specific antigen
- Screening
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Bjerner, Johan
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Bratt, Ola, 1963
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Aas, Kirsti
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Albertsen, Peter ...
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Fosså, Sophie D
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Kvåle, Rune
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visa fler...
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Lilja, Hans
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Müller, Christop ...
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Müller, Stig
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Stensvold, Andre ...
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Thomas, Owen
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Røe, Oluf D
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Vickers, Andrew
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Walz, Jochen
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Carlsson, Sigrid ...
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Oldenburg, Jan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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European Urology
- Av lärosätet
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Göteborgs universitet
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Lunds universitet