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Implementing data o...
Implementing data on targeted therapy from the INFORM registry platform for children with relapsed cancer in Sweden
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- Wallin, Sofia (author)
- Karolinska Institute,Karolinska Inst, Dept Women & Childrens Hlth, Div Pediat Oncol, Stockholm, Sweden.
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- Øra, Ingrid (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,Cancercellers evolution,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Pathways of cancer cell evolution,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Div Pediat Hematol Oncol, Lund, Sweden.;Lund Univ, Clin Sci IKVL, Lund, Sweden.
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- Prochazka, Gabriela (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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- Sandgren, Johanna (author)
- Karolinska Institutet
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- Bjorklund, Caroline (author)
- Umeå Univ Hosp, Div Pediat Hematol Oncol, Umeå, Sweden.,Norrland University Hospital
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- Ljungman, Gustaf, 1958- (author)
- Uppsala universitet,Uppsala University,Barnonkologisk forskning - särskilt fokus på komplikationer,Pediatric Hematology-Oncology
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- Vogt, Hartmut, MP, PhD, 1970- (author)
- Linköping University,Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus,Linköping Univ, Crown Princess Victor Childrens Hosp, Oncol B153, Div Pediat Hematol, Linköping, Sweden.;Linköping Univ, Dept Biomed & Clin Sci, Div Childrens & Womens Hlth, Linköping, Sweden.
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- Ek, Torben, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Univ Gothenburg, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Childrens Canc Ctr, Gothenburg, Sweden.,Sahlgrenska University Hospital
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- van Tilburg, Cornelis M. (author)
- Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany.;German Canc Res Ctr, Clin Cooperat Unit Pediat Oncol, Heidelberg, Germany.;Heidelberg Univ Hosp, Dept Pediat Oncol Hematol Immunol & Pulmonol, Heidelberg, Germany.;German Canc Consortium DKTK, Natl Ctr Tumor Dis NCT, Heidelberg, Germany.,German Cancer Research Centre
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- Nilsson, Anna (author)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Dept Women & Childrens Hlth, Div Pediat Oncol, Stockholm, Sweden.;Astrid Lindgren Childrens Hosp, Div Pediat Hematol Oncol, Tema Barn, Stockholm, Sweden.
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Karolinska Institute Karolinska Inst, Dept Women & Childrens Hlth, Div Pediat Oncol, Stockholm, Sweden (creator_code:org_t)
- FRONTIERS MEDIA SA, 2024
- 2024
- English.
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In: Frontiers in Oncology. - : FRONTIERS MEDIA SA. - 2234-943X. ; 14
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Abstract
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- Background Advances in treatment of childhood malignancies have improved overall cure rates to 80%. Nevertheless, cancer is still the most common cause of childhood mortality in Sweden. The prognosis is particularly poor for relapse of high-risk malignancies. In the international INFORM registry, tumor tissue from patients with relapsed, refractory, or progressive pediatric cancer as well as from very-high risk primary tumors is biologically characterized using next-generation sequencing to identify possible therapeutic targets. We analyzed data from Swedish children included in the INFORM registry concerning patient characteristics, survival, sequencing results and whether targeted treatment was administered to the children based on the molecular findings.Methods A registry-based descriptive analysis of 184 patients included in the INFORM registry in Sweden during 2016-2021.Results The most common diagnoses were soft tissue and bone sarcomas followed by high grade gliomas [including diffuse intrinsic pontine glioma (DIPG)]. Complete molecular analysis was successful for 203/212 samples originating from 184 patients. In 88% of the samples, at least one actionable target was identified. Highly prioritized targets, according to a preset scale, were identified in 48 (24%) samples from 40 patients and 24 of these patients received matched targeted treatment but only six children within a clinical trial. No statistically significant benefit in terms of overall survival or progression free survival was observed between children treated with matched targeted treatment compared to all others.Conclusion This international collaborative study demonstrate feasibility regarding sequencing of pediatric high-risk tumors providing molecular data regarding potential actionable targets to clinicians. For a few individuals the INFORM analysis was of utmost importance and should be regarded as a new standard of care with the potential to guide targeted therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- pediatric oncology
- pediatric cancer
- precision medicine
- molecular diagnostic techniques
- molecular targeted therapy
- pediatric oncology; pediatric cancer; precision medicine; molecular diagnostic techniques; molecular targeted therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wallin, Sofia
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Øra, Ingrid
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Prochazka, Gabri ...
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Sandgren, Johann ...
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Bjorklund, Carol ...
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Ljungman, Gustaf ...
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Vogt, Hartmut, M ...
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Ek, Torben, 1963
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van Tilburg, Cor ...
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Nilsson, Anna
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Frontiers in Onc ...
- By the university
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University of Gothenburg
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Linköping University
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Lund University
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Uppsala University
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Karolinska Institutet