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Reduction of macrop...
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss.
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Cancello, Raffaella (författare)
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Henega, Corneliu (författare)
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Viguerie, Nathalie (författare)
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visa fler...
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Taleb, Soraya (författare)
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Poitou, Christine (författare)
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Rouault, Christine (författare)
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Coupaye, Muriel (författare)
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Pelloux, Veronique (författare)
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Hugol, Danielle (författare)
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Bouillot, Jean-Luc (författare)
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Bouloumié, Anne (författare)
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Barbatelli, Giorgio (författare)
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Cinti, Saverio (författare)
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- Svensson, Per-Arne, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism
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Barsh, Gregory S. (författare)
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Zucker, Jean-Daniel (författare)
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Basdevant, Arnaud (författare)
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Langin, Dominique (författare)
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Clément, Karine (författare)
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visa färre...
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(creator_code:org_t)
- 2005
- 2005
- Engelska.
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Ingår i: Diabetes. - 0012-1797. ; 54:8, s. 2277-86
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- In human obesity, the stroma vascular fraction (SVF) of white adipose tissue (WAT) is enriched in macrophages. These cells may contribute to low-grade inflammation and to its metabolic complications. Little is known about the effect of weight loss on macrophages and genes involved in macrophage attraction. We examined subcutaneous WAT (scWAT) of 7 lean and 17 morbidly obese subjects before and 3 months after bypass surgery. Immunomorphological changes of the number of scWAT-infiltrating macrophages were evaluated, along with concomitant changes in expression of SVF-overexpressed genes. The number of scWAT-infiltrating macrophages before surgery was higher in obese than in lean subjects (HAM56+/CD68+; 22.6 +/- 4.3 vs. 1.4 +/- 0.6%, P < 0.001). Typical "crowns" of macrophages were observed around adipocytes. Drastic weight loss resulted in a significant decrease in macrophage number (-11.63 +/- 2.3%, P < 0.001), and remaining macrophages stained positive for the anti-inflammatory protein interleukin 10. Genes involved in macrophage attraction (monocyte chemotactic protein [MCP]-1, plasminogen activator urokinase receptor [PLAUR], and colony-stimulating factor [CSF]-3) and hypoxia (hypoxia-inducible factor-1alpha [HIF-1alpha]), expression of which increases in obesity and decreases after surgery, were predominantly expressed in the SVF. We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT.
Publikations- och innehållstyp
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Diabetes
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- Av författaren/redakt...
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Cancello, Raffae ...
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Henega, Corneliu
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Viguerie, Nathal ...
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Taleb, Soraya
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Poitou, Christin ...
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Rouault, Christi ...
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visa fler...
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Coupaye, Muriel
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Pelloux, Veroniq ...
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Hugol, Danielle
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Bouillot, Jean-L ...
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Bouloumié, Anne
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Barbatelli, Gior ...
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Cinti, Saverio
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Svensson, Per-Ar ...
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Barsh, Gregory S ...
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Zucker, Jean-Dan ...
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Basdevant, Arnau ...
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Langin, Dominiqu ...
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Clément, Karine
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visa färre...
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Diabetes
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Göteborgs universitet