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Svensson, Per Anders,1959Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg
(author)
Identification of genes predominantly expressed in human macrophages
- Article/chapterEnglish2004
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LIBRIS-ID:oai:gup.ub.gu.se/49809
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https://gup.ub.gu.se/publication/49809URI
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https://research.chalmers.se/publication/49809URI
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https://gup.ub.gu.se/publication/257362URI
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https://doi.org/10.1016/j.atherosclerosis.2004.07.031DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases.
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Hägg, Daniel,1974Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg(Swepub:cth)kb99heda
(author)
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Jernås, Margareta,1961Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg(Swepub:gu)xjernm
(author)
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Englund, Mikael C. O.,1971Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
(author)
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Mattsson Hultén, Lillemor,1951Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xmatli
(author)
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Ohlsson, Bertil,1954Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xohlbe
(author)
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Hulthe, Johannes,1970Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xhultj
(author)
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Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Wallenberglaboratoriet,Cardiovascular Institute,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xwikol
(author)
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Carlsson, Björn,1958Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine,University of Gothenburg(Swepub:gu)xcarbj
(author)
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Fagerberg, Björn,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Wallenberglaboratoriet,Institute of Internal Medicine, Dept of Medicine,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xfagbj
(author)
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Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism,University of Gothenburg(Swepub:gu)xcarle
(author)
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Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xsvper
(author)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism
(creator_code:org_t)
Related titles
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In:Atherosclerosis: Elsevier BV177, s. 287-290
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In:Atherosclerosis: Elsevier BV177, s. 287-2900021-9150
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- MEDICAL AND HEALTH SCIENCES
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- Atherosclerosis
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Atherosclerosis
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University of Gothenburg
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Chalmers University of Technology