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Lectin-reactive alp...
Lectin-reactive alpha-fetoprotein in patients with tyrosinemia type I and hepatocellular carcinoma.
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Baumann, Ulrich (author)
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Duhme, Valeska (author)
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Auth, Marcus K H (author)
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McKiernan, Patrick J (author)
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- Holme, Elisabeth, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2006
- 2006
- English.
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In: Journal of pediatric gastroenterology and nutrition. - : Ovid Technologies (Wolters Kluwer Health). - 0277-2116. ; 43:1, s. 77-82
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Despite the introduction of 2-(2-nitro-4-trifluormethyl-benzoyl)-1,3-cyclohexandion into the treatment of hereditary tyrosinemia type I (HT1), patients remain at risk of developing hepatocellular carcinoma (HCC). Serial total alpha-fetoprotein (AFP) levels are used to monitor the individual patient. Lectin-reactive alpha-fetoprotein (L3-AFP) is an AFP isoform that is expressed by malignant liver tumors. We investigated whether the analysis of L3-AFP could lead to earlier detection of HCC in HT1 compared with judgement based on total AFP alone. AFP electrophoresis using lectin-containing agarose gel identifies L3-AFP by the affinity of its specific carbohydrate chain to lectin. We report the retrospective analysis of sequential serum samples of 12 patients with HT1 and histologically proven HCC. AFP isoforms could be identified in all 12 patients. In 6 patients, the L3-AFP increased before the total AFP. In 3 patients, the rise in L3-AFP was parallel to the rise of total AFP; and in 3 patients, the L3-AFP was raised after the total AFP or did not increase at all. We were able to identify 6 of 12 patients with an early increase in the new tumor marker. Lectin-affinity electrophoresis may have a role in discriminating benign liver disease from HCC in HT1. We suggest the further evaluation of L3-AFP in HT1.
Keyword
- Adolescent
- Biological Markers
- blood
- Carcinoma
- Hepatocellular
- blood
- etiology
- Child
- Child
- Preschool
- Electrophoresis
- Agar Gel
- methods
- Follow-Up Studies
- Humans
- Infant
- Lectins
- metabolism
- Liver Neoplasms
- blood
- etiology
- Protein Isoforms
- blood
- Retrospective Studies
- Tumor Markers
- Biological
- blood
- Tyrosinemias
- blood
- complications
- alpha-Fetoproteins
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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