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Functional adaptati...
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Aspholm-Hurtig, MarinaUmeå universitet,Oral mikrobiologi
(author)
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin.
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2004
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/54720
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https://gup.ub.gu.se/publication/54720URI
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https://doi.org/10.1126/science.1098801DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6649URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-305728URI
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https://lup.lub.lu.se/record/141467URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1929360URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20211206
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Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O-dominant human populations.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Dailide, Giedrius
(author)
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Lahmann, Martina,1963Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry(Swepub:kth)u190mcjj
(author)
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Kalia, Awdhesh
(author)
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Ilver, Dag,1959Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
(author)
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Roche, NiamhLund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mig-nro
(author)
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Vikström, SusanneUmeå universitet,Oral mikrobiologi(Swepub:umu)suevim88
(author)
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Sjöström, RolfUmeå universitet,Oral mikrobiologi(Swepub:umu)rosj0001
(author)
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Lindén, Sara K.,1974Lund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)medk-sli
(author)
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Bäckström, AnnaUmeå universitet,Oral mikrobiologi(Swepub:umu)anba0003
(author)
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Lundberg, CarinaUmeå universitet,Oral mikrobiologi
(author)
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Arnqvist, AnnaUmeå universitet,Oral mikrobiologi,Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)anar0001
(author)
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Mahdavi, JafarUmeå universitet,Oral mikrobiologi
(author)
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Nilsson, UlfLund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)ok2-uni
(author)
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Velapatiño, Billie
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Gilman, Robert H
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Gerhard, Markus
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Alarcon, Teresa
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López-Brea, Manuel
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Nakazawa, Teruko
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Fox, James G
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Correa, Pelayo
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Dominguez-Bello, Maria Gloria
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Perez-Perez, Guillermo I
(author)
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Blaser, Martin J
(author)
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Normark, StaffanKarolinska Institutet
(author)
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Carlstedt, IngemarLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)medk-ica
(author)
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Oscarson, Stefan
(author)
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Teneberg, Susann,1955Gothenburg University,Göteborgs universitet,Institutionen för medicinsk och fysiologisk kemi,Institute of Medical Biochemistry(Swepub:gu)xtensu
(author)
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Berg, Douglas E
(author)
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Borén, ThomasUmeå universitet,Institutionen för medicinsk kemi och biofysik,Oral mikrobiologi(Swepub:umu)thbo0001
(author)
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Lind\’e;n, Sara
(author)
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Bor\’e;n, Thomas
(author)
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Umeå universitetOral mikrobiologi
(creator_code:org_t)
Related titles
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In:Science (New York, N.Y.): American Association for the Advancement of Science (AAAS)305:5683, s. 519-221095-92030036-8075
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Aspholm-Hurtig, ...
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Dailide, Giedriu ...
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Lahmann, Martina ...
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Kalia, Awdhesh
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Ilver, Dag, 1959
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Roche, Niamh
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show more...
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Vikström, Susann ...
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Sjöström, Rolf
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Lindén, Sara K., ...
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Bäckström, Anna
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Lundberg, Carina
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Arnqvist, Anna
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Mahdavi, Jafar
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Nilsson, Ulf
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Velapatiño, Bill ...
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Gilman, Robert H
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Gerhard, Markus
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Alarcon, Teresa
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López-Brea, Manu ...
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Nakazawa, Teruko
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Fox, James G
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Correa, Pelayo
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Dominguez-Bello, ...
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Perez-Perez, Gui ...
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Blaser, Martin J
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Normark, Staffan
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Carlstedt, Ingem ...
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Oscarson, Stefan
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Teneberg, Susann ...
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Berg, Douglas E
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Borén, Thomas
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Lind\’e;n, Sara
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Bor\’e;n, Thomas
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Karolinska Institutet