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Comparison of ST-se...
Comparison of ST-segment resolution with combined fibrinolytic and glycoprotein IIb/IIIa inhibitor therapy versus fibrinolytic alone (data from four clinical trials)
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Rebeiz, A. G. (author)
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- Johanson, Per, 1963 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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Green, C. L. (author)
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show more...
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Crater, S. W. (author)
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Roe, M. T. (author)
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Langer, A. (author)
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Giugliano, R. P. (author)
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Lincoff, A. M. (author)
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Newby, L. K. (author)
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Harrington, R. A. (author)
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Topol, E. J. (author)
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Califf, R. M. (author)
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Wagner, G. S. (author)
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Krucoff, M. W. (author)
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Am J Cardiol. - 0002-9149. ; 95:5, s. 611-4
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
Close
- We compared combination fibrinolytic plus glycoprotein IIb/IIIa inhibitor therapy with stand-alone fibrinolysis with respect to speed and stability of reperfusion in patients who had acute ST-segment elevation myocardial infarction; data were obtained from 654 patients in 4 trials (Integrilin to Manage Platelet Aggregation to Combat Thrombosis in Acute Myocardial Infarction, Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction, Integrilin and Tenecteplase in Acute Myocardial Infarction, and the Fifth Global Use of Strategies to Open Occluded Coronary Arteries) that compared thrombolytics plus lamifiban, eptifibatide, or abciximab with standard thrombolysis. We found significantly faster and more stable ST-segment recovery with combination therapy starting at 60 minutes (56.7% vs 48.0% with >/=50% ST-segment resolution, p = 0.03) and sustained over 180 minutes after drug administration; this transient benefit may suggest a time frame when more optimal percutaneous coronary intervention can be performed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Acetates/therapeutic use
- Aged
- Antibodies
- Monoclonal/therapeutic use
- Clinical Trials
- Drug Therapy
- Combination
- Electrocardiography
- Female
- Humans
- Immunoglobulin Fab Fragments/therapeutic use
- Male
- Middle Aged
- Myocardial Infarction/*drug therapy/mortality
- Peptides/therapeutic use
- Platelet Aggregation Inhibitors/*therapeutic use
- Platelet Glycoprotein GPIIb-IIIa Complex/*antagonists & inhibitors
- Streptokinase/therapeutic use
- Survival Analysis
- Thrombolytic Therapy/*methods
- Tissue Plasminogen Activator/therapeutic use
- Treatment Outcome
- Tyrosine/*analogs & derivatives/therapeutic use
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rebeiz, A. G.
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Johanson, Per, 1 ...
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Green, C. L.
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Crater, S. W.
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Roe, M. T.
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Langer, A.
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show more...
-
Giugliano, R. P.
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Lincoff, A. M.
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Newby, L. K.
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Harrington, R. A ...
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Topol, E. J.
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Califf, R. M.
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Wagner, G. S.
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Krucoff, M. W.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Am J Cardiol
- By the university
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University of Gothenburg