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Three insulin-relax...
Three insulin-relaxin-like genes in Ciona intestinalis
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- Olinski, Robert (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi,Hallböök
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- Dahlberg, Carl, 1974 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för marin ekologi,Department of Marine Ecology
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- Thorndyke, Michael C., 1946 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för marin ekologi,Department of Marine Ecology
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- Hallböök, Finn (författare)
- Uppsala universitet,Medicinsk utvecklingsbiologi,Hallböök
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Thorndyke, Mike (författare)
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- Engelska.
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Ingår i: Peptides. - : Elsevier BV. - 0196-9781 .- 1873-5169. ; 27:11, s. 2535-2546
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The Ciona intestinalis genome harbors three insulin-like genes: INS-L1, -L2 and -L3. Conserved synteny between the Ciona-human genomes predicts that Ciona INS-Ls are orthologous to the vertebrate insulin-relaxin family, but this relation cannot be inferred from molecular phylogeny. A conserved protein core with six cysteines; typical arrangement of B-, C- and A-protein domains; pro-protein maturation mode; and putative insulin receptor-binding sites were identified in Ciona INS-L proteins. ESTs used to assemble exonic sequences of INS-Ls combined with qRT-PCR analysis provided evidence that the predicted genes are expressed in the developing and adult Ciona. Our results support that Ciona INS-L1 is orthologous to the vertebrate insulin-like/relaxin genes, INS-L2 to insulin genies and INS-L3 to IGF genes. Our analysis also implies that the insulin-like/relaxin ancestor switched receptor type from tyrosine kinase- to GPCR-type, whereas insulin-IGF subfamily retained the tyrosine kinase-type of receptor. We propose that this receptor-switch occurred after the time when urochordates branched from the common chordate lineage, but before the two genome-duplications at the root of the vertebrates. (c) 2006 Elsevier Inc. All rights reserved.
Ämnesord
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Ciona intestinalis
- gene duplication
- IGF
- insulin
- insulin-like
- protein
- relaxin
- GROWTH-FACTOR-I
- CAENORHABDITIS-ELEGANS
- MOLECULAR EVOLUTION
- PEPTIDE
- FAMILY
- IGF-I
- AMPHIOXUS
- GENOME
- IDENTIFICATION
- SUPERFAMILY
- VERTEBRATES
- Ciona intestinalis
- MEDICINE
- Biology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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