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Osteoporosis in MCH...
Osteoporosis in MCHR1-deficient mice.
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- Bohlooly-Yeganeh, Mohammad, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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Mahlapuu, Margit, 1972 (author)
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Andersén, Harriet (author)
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Astrand, Annika (author)
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- Hjorth, Stephan, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi,Institute of Physiology and Pharmacology, Dept of Pharmacology
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Svensson, Lennart (author)
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- Törnell, Jan, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology
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Snaith, Michael R (author)
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Morgan, David G (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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(creator_code:org_t)
- Elsevier BV, 2004
- 2004
- English.
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In: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 318:4, s. 964-9
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- It is well recognized that the hypothalamus is of central importance in the regulation of food intake and fat mass. Recent studies indicate that it also plays an important role in the regulation of bone mass. Melanin concentrating hormone (MCH) is highly expressed in the hypothalamus and has been implicated in regulation of energy homeostasis. We developed MCHR1 inactivated mice to evaluate the physiological role of this receptor. Interestingly, the MCHR1(-/-) mice have osteoporosis, caused by a reduction in the cortical bone mass, while the amount of trabecular bone is unaffected. The reduction in cortical bone mass is due to decreased cortical thickness. Serum levels of c-telopeptide, a marker of bone resorption, are increased in MCHR1(-/-) mice, indicating that the MCHR1(-/-) mice have a high bone turnover osteoporosis. In conclusion, the MCHR1(-/-) mice have osteoporosis, indicating that MCHR1-signalling is involved in a tonic stimulation of bone mass.
Keyword
- Absorptiometry
- Photon
- Animals
- Biological Markers
- blood
- Bone Density
- physiology
- Bone Resorption
- blood
- Collagen
- blood
- Collagen Type I
- Female
- Femur
- chemistry
- pathology
- radiography
- Gene Components
- Gene Expression
- Hypothalamic Hormones
- metabolism
- Male
- Melanins
- metabolism
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Osteocalcin
- blood
- Osteoporosis
- blood
- genetics
- metabolism
- Peptides
- blood
- Pituitary Hormones
- metabolism
- RNA
- Messenger
- biosynthesis
- Receptors
- Pituitary Hormone
- deficiency
- genetics
- physiology
- Tissue Distribution
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bohlooly-Yeganeh ...
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Mahlapuu, Margit ...
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Andersén, Harrie ...
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Astrand, Annika
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Hjorth, Stephan, ...
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Svensson, Lennar ...
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show more...
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Törnell, Jan, 19 ...
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Snaith, Michael ...
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Morgan, David G
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Ohlsson, Claes, ...
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- Articles in the publication
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Biochemical and ...
- By the university
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University of Gothenburg