Sökning: onr:"swepub:oai:gup.ub.gu.se/78866" > Regulation of autop...
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000 | 04921naa a2200889 4500 | |
001 | oai:gup.ub.gu.se/78866 | |
003 | SwePub | |
008 | 240910s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/788662 URI |
024 | 7 | a https://doi.org/10.1038/ncb17302 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tasdemir, Ezgi4 aut |
245 | 1 0 | a Regulation of autophagy by cytoplasmic p53. |
264 | c 2008-05-04 | |
264 | 1 | b Springer Science and Business Media LLC,c 2008 |
520 | a Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that deletion, depletion or inhibition of p53 can induce autophagy in human, mouse and nematode cells subjected to knockout, knockdown or pharmacological inhibition of p53. Enhanced autophagy improved the survival of p53-deficient cancer cells under conditions of hypoxia and nutrient depletion, allowing them to maintain high ATP levels. Inhibition of p53 led to autophagy in enucleated cells, and cytoplasmic, not nuclear, p53 was able to repress the enhanced autophagy of p53(-/-) cells. Many different inducers of autophagy (for example, starvation, rapamycin and toxins affecting the endoplasmic reticulum) stimulated proteasome-mediated degradation of p53 through a pathway relying on the E3 ubiquitin ligase HDM2. Inhibition of p53 degradation prevented the activation of autophagy in several cell lines, in response to several distinct stimuli. These results provide evidence of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a Animals | |
653 | a Anoxia | |
653 | a Autophagy | |
653 | a Cell Line | |
653 | a Tumor | |
653 | a Cytoplasm | |
653 | a metabolism | |
653 | a Endoplasmic Reticulum | |
653 | a metabolism | |
653 | a Gene Expression Regulation | |
653 | a Genes | |
653 | a p53 | |
653 | a Humans | |
653 | a Lysosomes | |
653 | a metabolism | |
653 | a Mice | |
653 | a Mice | |
653 | a Transgenic | |
653 | a Models | |
653 | a Biological | |
653 | a Proteasome Endopeptidase Complex | |
653 | a metabolism | |
653 | a Tumor Suppressor Protein p53 | |
653 | a metabolism | |
653 | a physiology | |
700 | 1 | a Maiuri, M Chiara4 aut |
700 | 1 | a Galluzzi, Lorenzo4 aut |
700 | 1 | a Vitale, Ilio4 aut |
700 | 1 | a Djavaheri-Mergny, Mojgan4 aut |
700 | 1 | a D'Amelio, Marcello4 aut |
700 | 1 | a Criollo, Alfredo4 aut |
700 | 1 | a Morselli, Eugenia4 aut |
700 | 1 | a Zhu, Changlian,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation4 aut0 (Swepub:gu)xzhuch |
700 | 1 | a Harper, Francis4 aut |
700 | 1 | a Nannmark, Ulf,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology4 aut0 (Swepub:gu)xnanul |
700 | 1 | a Samara, Chrysanthi4 aut |
700 | 1 | a Pinton, Paolo4 aut |
700 | 1 | a Vicencio, José Miguel4 aut |
700 | 1 | a Carnuccio, Rosa4 aut |
700 | 1 | a Moll, Ute M4 aut |
700 | 1 | a Madeo, Frank4 aut |
700 | 1 | a Paterlini-Brechot, Patrizia4 aut |
700 | 1 | a Rizzuto, Rosario4 aut |
700 | 1 | a Szabadkai, Gyorgy4 aut |
700 | 1 | a Pierron, Gérard4 aut |
700 | 1 | a Blomgren, Klas,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institutionen för kliniska vetenskaper,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation,Institute of Clinical Sciences4 aut0 (Swepub:gu)xblokl |
700 | 1 | a Tavernarakis, Nektarios4 aut |
700 | 1 | a Codogno, Patrice4 aut |
700 | 1 | a Cecconi, Francesco4 aut |
700 | 1 | a Kroemer, Guido4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering4 org |
773 | 0 | t Nature cell biologyd : Springer Science and Business Media LLCg 10:6, s. 676-87q 10:6<676-87x 1476-4679x 1465-7392 |
856 | 4 | u https://europepmc.org/articles/pmc2676564?pdf=render |
856 | 4 8 | u https://gup.ub.gu.se/publication/78866 |
856 | 4 8 | u https://doi.org/10.1038/ncb1730 |
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