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Relapses in multipl...
Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF.
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- Malmeström, Clas, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Lycke, Jan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Haghighi, Sara (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Andersen, Oluf, 1941 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Carlsson, Lena M S, 1957 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Wadenvik, Hans, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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- Olsson, Bob, 1969 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Journal of neuroimmunology. - : Elsevier BV. - 0165-5728. ; 196:1-2, s. 159-65
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Abstract
Subject headings
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- MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses.
Keyword
- Adult
- Antigens
- CD8
- genetics
- metabolism
- Antigens
- Differentiation
- T-Lymphocyte
- genetics
- metabolism
- CD8-Positive T-Lymphocytes
- metabolism
- Dipeptidyl Peptidase I
- genetics
- metabolism
- Female
- Flow Cytometry
- methods
- Gene Expression
- Gene Expression Regulation
- physiology
- Granzymes
- blood
- cerebrospinal fluid
- genetics
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
- Relapsing-Remitting
- cerebrospinal fluid
- pathology
- Oligonucleotide Array Sequence Analysis
- methods
- Perforin
- genetics
- metabolism
- RNA
- Messenger
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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Malmeström, Clas ...
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Lycke, Jan, 1956
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Haghighi, Sara
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Andersen, Oluf, ...
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Carlsson, Lena M ...
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Wadenvik, Hans, ...
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Olsson, Bob, 196 ...
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Journal of neuro ...
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University of Gothenburg