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Recruitment of T ce...
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Olsson, Bob,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
(författare)
Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1.
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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American Society of Hematology,2008
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/87654
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https://gup.ub.gu.se/publication/87654URI
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https://doi.org/10.1182/blood-2008-02-139402DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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In idiopathic thrombocytopenic purpura (ITP), platelets are destroyed in the spleen, liver, and bone marrow (BM) by autoantibodies and cytotoxic T cells. In a DNA microarray screen of peripheral blood T cells, we found that VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients compared with controls. However, we only found increased protein expression of VLA-4 on T cells from peripheral blood by flow cytometry. To address a possible recruitment of T cells into the organs involved in platelet destruction, we analyzed T cells in BM. In BM, T-cell surface expression of VLA-4 and CX3CR1 was increased in ITP patients compared with controls. Furthermore, the number of CD3(+) T cells in BM, but not in blood, was increased in ITP patients compared with controls. This finding was confirmed by immunohistochemistry of BM biopsies. The number of regulatory T cells (CD4(+)/CD25(bright)) was decreased in the BM of ITP patients, whereas Fas expression was increased. In conclusion, ITP is associated with accumulation and activation of T cells in the BM. Recruitment of T cells into the target organ (eg, BM) is plausible and may be facilitated through increased VLA-4 and CX3CR1 expression. These molecules might serve as new treatment targets in ITP.
Ämnesord och genrebeteckningar
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Adolescent
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Adult
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Aged
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Bone Marrow
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pathology
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Cell Movement
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Female
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Gene Expression Profiling
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Humans
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Immunity
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Integrin alpha4beta1
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genetics
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Male
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Middle Aged
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Purpura
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Thrombocytopenic
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Idiopathic
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immunology
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Receptors
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CXCR4
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genetics
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Receptors
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Chemokine
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genetics
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T-Lymphocyte Subsets
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T-Lymphocytes
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physiology
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Up-Regulation
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genetics
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ridell, BörjeGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology
(författare)
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Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcarle
(författare)
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Jacobsson, Stefan,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine(Swepub:gu)xjacst
(författare)
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Wadenvik, Hans,1955Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine(Swepub:gu)xwadha
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood: American Society of Hematology112:4, s. 1078-841528-00200006-4971
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