onr:"swepub:oai:lup.lub.lu.se:00ea76b8-aea6-4e7d-b9fb-fa5696902942"
Sökning: onr:"swepub:oai:lup.lub.lu.se:00ea76b8-aea6-4e7d-b9fb-fa5696902942" > Evidence of airway ...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03329naa a2200313 4500 | |
| 001 | oai:lup.lub.lu.se:00ea76b8-aea6-4e7d-b9fb-fa5696902942 | |
| 003 | SwePub | |
| 008 | 160401s2000 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11166742 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Karjalainen, E M4 aut |
| 245 | 1 0 | a Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine |
| 264 | 1 | c 2000 |
| 520 | a Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascin expression in the subepithelial basement membrane in endobronchial biopsy specimens of the proximal airways from 40 elite, competitive skiers (mean: 17.5; range: 16 to 20 yr) without a diagnosis of asthma, in 12 subjects with mild asthma, and in 12 healthy controls, through immunohistochemistry and indirect immunofluorescence, respectively. All of the subjects were nonsmokers. T-lymphocyte, macrophage, and eosinophil counts were, respectively, greater by 43-fold (p < 0.001), 26-fold (p < 0.001), and twofold (p < 0.001) in skiers, and by 70-fold (p < 0.001), 63-fold (p < 0.001), and eightfold (p < 0.001) in asthmatic subjects than in controls. In skiers, neutrophil counts were more than twofold greater than in asthmatic subjects, and mast cell counts were not significantly different than in controls. Tenascin expression (as measured through the thickness of the tenascin-specific immunoreactivity band in the basement membrane) was increased in skiers (median: 6.7 microm; interquartile range [IQR]: 5.3 to 8.5 microm, p < 0.001) and asthmatic subjects (mean: 8.8 microm; IQR: 7.2 to 10.8 microm, p < 0. 001) compared with controls (mean: 0.8 microm; IQR: 0 to 3.1 microm) and did not correlate with inflammatory cell counts. Inflammatory changes were present irrespective of asthmalike symptoms, hyperresponsiveness, or atopy. Prolonged repeated exposure of the airways to inadequately conditioned air may induce inflammation and remodeling in competitive skiers. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
| 700 | 1 | a Laitinen, A4 aut |
| 700 | 1 | a Sue-Chu, M4 aut |
| 700 | 1 | a Altraja, A4 aut |
| 700 | 1 | a Bjermer, Leifu Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)lung-lbj |
| 700 | 1 | a Laitinen, L A4 aut |
| 710 | 2 | a Lungmedicin, allergologi och palliativ medicinb Sektion II4 org |
| 773 | 0 | t American Journal of Respiratory and Critical Care Medicineg 161:6, s. 2086-2091q 161:6<2086-2091x 1535-4970 |
| 856 | 4 | u http://ajrccm.atsjournals.org/cgi/content/full/161/6/2086x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1116674 |
Hitta via bibliotek
- American Journal of Respiratory and Critical Care Medicine (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Karjalainen, E M
- Laitinen, A
- Sue-Chu, M
- Altraja, A
- Bjermer, Leif
- Laitinen, L A
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Lungmedicin och ...
- Artiklar i publikationen
- American Journal ...
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
