Search: onr:"swepub:oai:lup.lub.lu.se:066bd8c2-7719-4060-ad52-f159f8e3ec56" >
The GTP-binding pro...
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons
-
Errico, Francesco (author)
-
- Santini, Emanuela (author)
- Karolinska Institutet
-
Migliarini, Sara (author)
-
show more...
-
- Borgkvist, Anders (author)
- Karolinska Institutet
-
Centonze, Diego (author)
-
Nasti, Valentina (author)
-
- Carta, Manolo (author)
- Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Neurobiology,Lund University Research Groups
-
De Chiara, Valentina (author)
-
Prosperetti, Chiara (author)
-
Spano, Daniela (author)
-
Herve, Denis (author)
-
Pasqualetti, Massimo (author)
-
Di Lauro, Roberto (author)
-
- Fisone, Gilberto (author)
- Karolinska Institutet
-
Usiello, Alessandro (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
-
In: Molecular and Cellular Neuroscience. - : Elsevier BV. - 1044-7431. ; 37:2, s. 335-345
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Rhes is a small GTP-binding protein prominently localized in the striatum. Previous findings obtained in cell culture systems demonstrated an involvement of Rhes in cAMP/PKA signalling pathway, at a level proximal to the activation of heterotrimeric G-protein complex. However, its role in the striatum has been, so far, only supposed. Here we studied the involvement of Rhes in dopaminergic signalling, by employing mice with a null mutation in the Rhes gene. We demonstrated that the absence of Rhes modulates cAMP/PKA signalling in both striatopallidal and striatonigral projection neurons by increasing Golf. protein levels and, in turn, influencing motor responses challenged by dopaminergic agonist/antagonist. Interestingly, we also show that Rhes is required for a correct dopamine-mediated GTP binding, a function mainly associated to stimulation of dopamine D2 receptors. Altogether, our results indicate that Rhes is an important modulator of dopaminergic transmission in the striatum.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- signal
- knockout mice
- striatum
- G-protien coupled receptor
- dopamine
- transduction
- medium spiny neurons
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Errico, Francesc ...
-
Santini, Emanuel ...
-
Migliarini, Sara
-
Borgkvist, Ander ...
-
Centonze, Diego
-
Nasti, Valentina
-
show more...
-
Carta, Manolo
-
De Chiara, Valen ...
-
Prosperetti, Chi ...
-
Spano, Daniela
-
Herve, Denis
-
Pasqualetti, Mas ...
-
Di Lauro, Robert ...
-
Fisone, Gilberto
-
Usiello, Alessan ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Molecular and Ce ...
- By the university
-
Lund University
-
Karolinska Institutet