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Effect of dimethyl ...
Effect of dimethyl fumarate on mitochondrial metabolism in a pediatric porcine model of asphyxia-induced in-hospital cardiac arrest
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- Piel, Sarah (författare)
- Heinrich Heine University Düsseldorf,University Hospital of Düsseldorf,The Children's Hospital of Philadelphia
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- McManus, Meagan J. (författare)
- The Children's Hospital of Philadelphia
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- Heye, Kristina N. (författare)
- The Children's Hospital of Philadelphia
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- Beaulieu, Forrest (författare)
- The Children's Hospital of Philadelphia
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- Fazelinia, Hossein (författare)
- The Children's Hospital of Philadelphia
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- Janowska, Joanna I. (författare)
- The Children's Hospital of Philadelphia
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- MacTurk, Bryce (författare)
- The Children's Hospital of Philadelphia
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- Starr, Jonathan (författare)
- The Children's Hospital of Philadelphia
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- Gaudio, Hunter (författare)
- The Children's Hospital of Philadelphia
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- Patel, Nisha (författare)
- The Children's Hospital of Philadelphia
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- Hefti, Marco M. (författare)
- University of Iowa Carver College of Medicine
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- Smalley, Martin E. (författare)
- University of Iowa Carver College of Medicine
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- Hook, Jordan N. (författare)
- University of Iowa Carver College of Medicine
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- Kohli, Neha V. (författare)
- The Children's Hospital of Philadelphia
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- Bruton, James (författare)
- The Children's Hospital of Philadelphia
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- Hallowell, Thomas (författare)
- The Children's Hospital of Philadelphia
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- Delso, Nile (författare)
- The Children's Hospital of Philadelphia
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- Roberts, Anna (författare)
- The Children's Hospital of Philadelphia
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- Lin, Yuxi (författare)
- The Children's Hospital of Philadelphia
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- Ehinger, Johannes K. (författare)
- Lund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Mitokondriell Medicin,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Mitochondrial Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Karlsson, Michael (författare)
- Copenhagen University Hospital
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- Berg, Robert A. (författare)
- The Children's Hospital of Philadelphia
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- Morgan, Ryan W. (författare)
- The Children's Hospital of Philadelphia
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- Kilbaugh, Todd J. (författare)
- The Children's Hospital of Philadelphia
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Scientific Reports. - 2045-2322. ; 14:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Neurological and cardiac injuries are significant contributors to morbidity and mortality following pediatric in-hospital cardiac arrest (IHCA). Preservation of mitochondrial function may be critical for reducing these injuries. Dimethyl fumarate (DMF) has shown potential to enhance mitochondrial content and reduce oxidative damage. To investigate the efficacy of DMF in mitigating mitochondrial injury in a pediatric porcine model of IHCA, toddler-aged piglets were subjected to asphyxia-induced CA, followed by ventricular fibrillation, high-quality cardiopulmonary resuscitation, and random assignment to receive either DMF (30 mg/kg) or placebo for four days. Sham animals underwent similar anesthesia protocols without CA. After four days, tissues were analyzed for mitochondrial markers. In the brain, untreated CA animals exhibited a reduced expression of proteins of the oxidative phosphorylation system (CI, CIV, CV) and decreased mitochondrial respiration (p < 0.001). Despite alterations in mitochondrial content and morphology in the myocardium, as assessed per transmission electron microscopy, mitochondrial function was unchanged. DMF treatment counteracted 25% of the proteomic changes induced by CA in the brain, and preserved mitochondrial structure in the myocardium. DMF demonstrates a potential therapeutic benefit in preserving mitochondrial integrity following asphyxia-induced IHCA. Further investigation is warranted to fully elucidate DMF’s protective mechanisms and optimize its therapeutic application in post-arrest care.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Asphyxia
- Brain
- Cardiac arrest
- Dimethyl fumarate
- Heart
- Metabolism
- Mitochondria
- Post-arrest care
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Piel, Sarah
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McManus, Meagan ...
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Heye, Kristina N ...
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Beaulieu, Forres ...
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Fazelinia, Hosse ...
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Janowska, Joanna ...
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visa fler...
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MacTurk, Bryce
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Starr, Jonathan
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Gaudio, Hunter
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Patel, Nisha
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Hefti, Marco M.
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Smalley, Martin ...
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Hook, Jordan N.
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Kohli, Neha V.
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Bruton, James
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Hallowell, Thoma ...
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Delso, Nile
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Roberts, Anna
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Lin, Yuxi
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Ehinger, Johanne ...
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Karlsson, Michae ...
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Berg, Robert A.
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Morgan, Ryan W.
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Kilbaugh, Todd J ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Scientific Repor ...
- Av lärosätet
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Lunds universitet