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Accelerating vaccin...
Accelerating vaccine manufacturing development through model-based approaches : current advances and future opportunities
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- Ramin, Elham (author)
- Technical University of Denmark
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Cardillo, Antonio Gaetano (author)
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- Liebers, Reinhard (author)
- European Vaccine Initiative - EWIV
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- Schmölder, Johannes (author)
- Jülich Research Centre
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- von Lieres, Eric (author)
- Jülich Research Centre
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Van Molle, Wim (author)
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- Niebel, Bastian (author)
- Insilico Biotechnology AG
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- Natalis, Laurent (author)
- PharmaLex Belgium
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Meln, Irina (author)
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- Perea-Vélez, Mónica (author)
- GlaxoSmithKline Pharmaceuticals SA
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- Clénet, Didier (author)
- Sanofi S.A., France
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- Jørgensen, John Bagterp (author)
- Technical University of Denmark
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- Nilsson, Bernt (author)
- Lund University,Lunds universitet,Processindustriellt centrum vid Lunds universitet, PIC-LU,Annan verksamhet, LTH,Lunds Tekniska Högskola,Avdelningen för kemiteknik,Institutionen för processteknik och tillämpad biovetenskap,Institutioner vid LTH,Process Industry Centre at Lund University, PIC-LU,Other operations, LTH,Faculty of Engineering, LTH,Division of Chemical Engineering,Department of Process and Life Science Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Bracewell, Daniel G. (author)
- University College London
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- Gernaey, Krist V. (author)
- Technical University of Denmark
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Current Opinion in Chemical Engineering. - 2211-3398. ; 43
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Abstract
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- This review highlights the importance of model-based approaches in accelerating vaccine manufacturing process development. The challenges of scaling up from laboratory to commercial processes are addressed through the adoption of Process Analytical Technology frameworks and Quality by Design principles. The application of various modeling approaches beyond downstream and upstream processes in vaccine production is discussed in detail. These in silico process simulation approaches enable deeper understanding of manufacturing dynamics, identification of critical process parameters, and the development of well-defined design spaces, ultimately leading to accelerated vaccine development and improved product quality. The authors stress the significance of an integrated modeling platform for vaccine manufacturing, exemplified by the Inno4Vac project. This initiative seeks to develop a comprehensive computational platform for vaccine manufacturing and stability testing, with a particular focus on stakeholder engagement and collaboration with regulatory bodies to ensure the acceptance and implementation of the platform.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Bearbetnings-, yt- och fogningsteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Manufacturing, Surface and Joining Technology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Kemiska processer (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Chemical Process Engineering (hsv//eng)
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Ramin, Elham
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Cardillo, Antoni ...
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Liebers, Reinhar ...
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Schmölder, Johan ...
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von Lieres, Eric
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Van Molle, Wim
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show more...
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Niebel, Bastian
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Natalis, Laurent
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Meln, Irina
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Perea-Vélez, Món ...
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Clénet, Didier
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Jørgensen, John ...
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Nilsson, Bernt
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Bracewell, Danie ...
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Gernaey, Krist V ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Materials Engine ...
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and Manufacturing Su ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Chemical Enginee ...
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Lund University