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Sökning: onr:"swepub:oai:lup.lub.lu.se:0e09c420-e5ed-417d-9e76-db0c4a391c3a" > Anthropometric and ...

  • Sanikini, HarinakshiImperial College London (författare)

Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite : Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2019-05-21
  • Wiley,2020
  • 14 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:0e09c420-e5ed-417d-9e76-db0c4a391c3a
  • https://lup.lub.lu.se/record/0e09c420-e5ed-417d-9e76-db0c4a391c3aURI
  • https://doi.org/10.1002/ijc.32386DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144909394URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Muller, David C.Imperial College London (författare)
  • Sophiea, MarisaImperial College London (författare)
  • Rinaldi, SabinaInternational Agency for Research on Cancer, World Health Organization (författare)
  • Agudo, AntonioCatalan Institute of Oncology (författare)
  • Duell, Eric J.Catalan Institute of Oncology (författare)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute,Folkhälsan Research Center,University of Helsinki,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø (författare)
  • Overvad, KimAarhus University (författare)
  • Tjønneland, AnneDanish Cancer Society (författare)
  • Halkjær, JytteDanish Cancer Society (författare)
  • Boutron-Ruault, Marie ChristineUniversity of Paris-Saclay,Institut Gustave Roussy (författare)
  • Carbonnel, FranckInstitut Gustave Roussy,Bicêtre Hospital,University of Paris-Saclay (författare)
  • Cervenka, IrisInstitut Gustave Roussy,University of Paris-Saclay (författare)
  • Boeing, HeinerGerman Institute of Human Nutrition (författare)
  • Kaaks, RudolfGerman Cancer Research Centre (författare)
  • Kühn, TilmanGerman Cancer Research Centre (författare)
  • Trichopoulou, AntoniaHellenic Health Foundation, Athens (författare)
  • Martimianaki, GeorgiaHellenic Health Foundation, Athens (författare)
  • Karakatsani, AnnaHellenic Health Foundation, Athens,National and Kapodistrian University of Athens,Attikon University Hospital (författare)
  • Pala, ValeriaIstituto Nazionale dei Tumori (författare)
  • Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (författare)
  • Mattiello, AmaliaUniversity of Naples Federico II (författare)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (författare)
  • Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin (författare)
  • Skeie, GuriUiT The Arctic University of Norway, Tromsø (författare)
  • Rylander, CharlottaUiT The Arctic University of Norway, Tromsø (författare)
  • Chirlaque López, María DoloresMurcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP),University of Murcia (författare)
  • Sánchez, Maria JoseUniversity of Granada,Hospital Clínico Universitario San Cecilio,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP),Navarre Public Health Institute (ISPN)(Swepub:lu)extLU-05 (författare)
  • Regnér, SaraLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-sre (författare)
  • Stocks, TanjaLund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)med-tss (författare)
  • Bueno-de-Mesquita, BasImperial College London,University of Malaya,National Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht (författare)
  • Vermeulen, Roel C.H.Utrecht University,University Medical Center Utrecht (författare)
  • Aune, DagfinnBjørknes University College,Oslo university hospital,Imperial College London (författare)
  • Tong, Tammy Y.N.University of Oxford (författare)
  • Kliemann, NathalieInternational Agency for Research on Cancer, World Health Organization (författare)
  • Murphy, NeilInternational Agency for Research on Cancer, World Health Organization (författare)
  • Chadeau-Hyam, MarcImperial College London (författare)
  • Gunter, Marc J.International Agency for Research on Cancer, World Health Organization (författare)
  • Cross, Amanda J.Imperial College London (författare)
  • Imperial College LondonInternational Agency for Research on Cancer, World Health Organization (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Cancer: Wiley146:4, s. 929-9420020-71361097-0215

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