Sökning: onr:"swepub:oai:lup.lub.lu.se:11e94b1d-0994-4543-980a-805429c583af" > Reduction of Abeta ...
Fältnamn | Indikatorer | Metadata |
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000 | 03775naa a2200421 4500 | |
001 | oai:lup.lub.lu.se:11e94b1d-0994-4543-980a-805429c583af | |
003 | SwePub | |
008 | 170223s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11e94b1d-0994-4543-980a-805429c583af2 URI |
024 | 7 | a https://doi.org/10.1038/srep418022 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Harach, T.u Swiss Federal Institute of Technology4 aut |
245 | 1 0 | a Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota |
264 | c 2017-02-08 | |
264 | 1 | b Springer Science and Business Media LLC,c 2017 |
520 | a Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known. To this end we sequenced bacterial 16S rRNA from fecal samples of Aβ precursor protein (APP) transgenic mouse model and found a remarkable shift in the gut microbiota as compared to non-transgenic wild-type mice. Subsequently we generated germ-free APP transgenic mice and found a drastic reduction of cerebral Aβ amyloid pathology when compared to control mice with intestinal microbiota. Importantly, colonization of germ-free APP transgenic mice with microbiota from conventionally-raised APP transgenic mice increased cerebral Aβ pathology, while colonization with microbiota from wild-type mice was less effective in increasing cerebral Aβ levels. Our results indicate a microbial involvement in the development of Abeta amyloid pathology, and suggest that microbiota may contribute to the development of neurodegenerative diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Marungruang, N.u Lund University,Lunds universitet,Centrum för preventiv livsmedelsforskning,Universitetets särskilda verksamheter,Food for Health Science Centre,University Specialised Centres4 aut0 (Swepub:lu)appl-nym |
700 | 1 | a Duthilleul, N.u Swiss Federal Institute of Technology4 aut |
700 | 1 | a Cheatham, V.u Swiss Federal Institute of Technology4 aut |
700 | 1 | a Mc Coy, K. D.u University of Bern4 aut |
700 | 1 | a Frisoni, G. B.u Geneva University Hospital,University of Geneva4 aut |
700 | 1 | a Neher, J. J.u German Center for Neurodegenerative Diseases (DZNE), Bonn,University of Tübingen4 aut |
700 | 1 | a Fåk, F.u Lund University,Lunds universitet,Centrum för preventiv livsmedelsforskning,Universitetets särskilda verksamheter,Food for Health Science Centre,University Specialised Centres4 aut0 (Swepub:lu)cob-ffa |
700 | 1 | a Jucker, Mathiasu University of Tübingen,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Lasser, Theou Swiss Federal Institute of Technology4 aut |
700 | 1 | a Bolmont, T.u Swiss Federal Institute of Technology,Stemedica International4 aut |
710 | 2 | a Swiss Federal Institute of Technologyb Centrum för preventiv livsmedelsforskning4 org |
773 | 0 | t Scientific Reportsd : Springer Science and Business Media LLCg 7q 7x 2045-2322 |
856 | 4 | u http://dx.doi.org/10.1038/srep41802x freey FULLTEXT |
856 | 4 | u https://www.nature.com/articles/srep41802.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/11e94b1d-0994-4543-980a-805429c583af |
856 | 4 8 | u https://doi.org/10.1038/srep41802 |
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