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PBB3 imaging in Par...
PBB3 imaging in Parkinsonian disorders : Evidence for binding to tau and other proteins
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- Perez-Soriano, Alexandra (författare)
- University of British Columbia
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- Arena, Julieta E (författare)
- University of British Columbia
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- Dinelle, Katie (författare)
- University of British Columbia
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- Miao, Qing (författare)
- TRIUMF
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- McKenzie, Jessamyn (författare)
- University of British Columbia
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- Neilson, Nicole (författare)
- University of British Columbia
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- Puschmann, Andreas (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk neurogenetik,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Neurogenetics,Lund University Research Groups,Skåne University Hospital
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- Schaffer, Paul (författare)
- TRIUMF
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- Shinotoh, Hitoshi (författare)
- National Institute of Radiological Sciences, Japan
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- Smith-Forrester, Jenna (författare)
- University of British Columbia
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- Shahinfard, Elham (författare)
- University of British Columbia
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Vafai, Nasim (författare)
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Wile, Daryl (författare)
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Wszolek, Zbigniew K (författare)
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Higuchi, Makoto (författare)
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Sossi, Vesna (författare)
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- Stoessl, A. Jon (författare)
- University of British Columbia
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(creator_code:org_t)
- 2017-06-01
- 2017
- Engelska.
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Ingår i: Movement Disorders. - : Wiley. - 0885-3185. ; 32:7, s. 1016-1024
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND AND OBJECTIVES: To study selective regional binding for tau pathology in vivo, using PET with [(11) C]PBB3 in PSP patients, and other conditions not typically associated with tauopathy.METHODS: Dynamic PET scans were obtained for 70 minutes after the bolus injection of [(11) C]PBB3 in 5 PSP subjects, 1 subject with DCTN1 mutation and PSP phenotype, 3 asymptomatic SNCA duplication carriers, 1 MSA subject, and 6 healthy controls of similar age. Tissue reference Logan analysis was applied to each region of interest using a cerebellar white matter reference region.RESULTS: In comparison to the control group, PSP subjects showed specific uptake of [(11) C]PBB3 in putamen, midbrain, GP, and SN. Longer disease duration and more advanced clinical severity were generally associated with higher tracer retention. A DCTN1/PSP phenotype case showed increased binding in putamen, parietal lobe, and GP. In SNCA duplication carriers, there was a significant increase of [(11) C] PBB3 binding in GP, putamen, thalamus, ventral striatum, SN, and pedunculopontine nucleus. The MSA case showed increased binding in frontal lobe, GP, midbrain, parietal lobe, putamen, temporal lobe, SN, thalamus, and ventral striatum.CONCLUSIONS: All PSP patients showed increased retention of the tracer in the basal ganglia, as expected. Binding was also present in asymptomatic SNCA duplication carriers and in an MSA case, which are not typically associated with pathological tau deposition. This suggests the possibility that [(11) C]PBB3 binds to alpha-synuclein. © 2017 International Parkinson and Movement Disorder Society.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Perez-Soriano, A ...
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Arena, Julieta E
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Dinelle, Katie
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Miao, Qing
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McKenzie, Jessam ...
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Neilson, Nicole
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visa fler...
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Puschmann, Andre ...
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Schaffer, Paul
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Shinotoh, Hitosh ...
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Smith-Forrester, ...
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Shahinfard, Elha ...
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Vafai, Nasim
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Wile, Daryl
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Wszolek, Zbignie ...
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Higuchi, Makoto
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Sossi, Vesna
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Stoessl, A. Jon
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Movement Disorde ...
- Av lärosätet
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Lunds universitet