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Healthcare resource...
Healthcare resource use of patients with transthyretin amyloid cardiomyopathy
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Lauppe, Rosa (author)
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- Liseth Hansen, Johan (author)
- University of Oslo
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Fornwall, Anna (author)
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Johansson, Katarina (author)
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- Rozenbaum, Mark H. (author)
- Pfizer Inc. US
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- Strand, Anne Mette (author)
- Pfizer Inc. US
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- Vakevainen, Merja (author)
- Pfizer Inc. US
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- Kuusisto, Johanna (author)
- University of Eastern Finland
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- Gude, Einar (author)
- Norwegian Radium Hospital
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- Smith, J. Gustav (author)
- Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Gustafsson, Finn (author)
- Copenhagen University Hospital
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University of Oslo Pfizer Inc US (creator_code:org_t)
- 2022-04
- 2022
- English 7 s.
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In: ESC Heart Failure. - : Wiley. - 2055-5822. ; 9:3, s. 1636-1642
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Abstract
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- Aims: Transthyretin amyloid cardiomyopathy (ATTR-CM) is the cardiac manifestation of transthyretin amyloidosis (ATTR). The aim of this study was to estimate healthcare resource use for ATTR-CM patients compared with heart failure (HF) patients, in Denmark, Finland, Norway, and Sweden. Methods and results: Data from nationwide healthcare registers in the four countries were used. ATTR-CM patients were defined as individuals diagnosed with amyloidosis and cardiomyopathy or HF between 2008 and 2018. Patients in the ATTR-CM cohort were matched to patients with HF but without ATTR-CM diagnosis. Resource use included number of visits to specialty outpatient and inpatient hospital care. A total of 1831 ATTR-CM and 1831 HF patients were included in the analysis. The mean number of hospital-based healthcare contacts increased in both the ATTR-CM and HF cohort during 3 years pre-diagnosis and was consistently higher for the ATTR-CM cohort compared with the HF cohort, with 6.1 [CI: 5.9–6.3] vs. 3.2 [CI: 3.1–3.3] outpatient visits and 1.03 [CI: 0.96–1.1] vs. 0.7 [CI: 0.7–0.8] hospitalizations. In the first year following diagnosis, patients with ATTR-CM continued to visit outpatient care (10.2 [CI: 10.1, 10.4] vs. 5.7 [CI: 5.6, 5.9]) and were admitted to hospital more frequently (3.3 [CI: 3.2, 3.4] vs. 2.5 [CI: 2.5, 2.6]) than HF patients. Conclusions: Transthyretin amyloid cardiomyopathy imposes a high burden on healthcare systems with twice as many outpatient specialist visits and 50% more hospitalizations in the year after diagnosis compared with HF patients without ATTR-CM. Studies to investigate if earlier diagnosis and treatment of ATTR-CM may lower resource use are warranted.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Burden
- Cardiomyopathy
- Healthcare resource use
- Heart failure
- TTR amyloidosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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Lauppe, Rosa
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Liseth Hansen, J ...
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Fornwall, Anna
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Johansson, Katar ...
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Rozenbaum, Mark ...
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Strand, Anne Met ...
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show more...
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Vakevainen, Merj ...
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Kuusisto, Johann ...
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Gude, Einar
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Smith, J. Gustav
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Gustafsson, Finn
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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MEDICAL AND HEAL ...
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- Articles in the publication
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ESC Heart Failur ...
- By the university
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Lund University
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University of Gothenburg