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Complications of su...
Complications of surgery for gastro-entero-pancreatic neuroendocrine neoplasias
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- Albers, Max B. (författare)
- Lund University,Philipp University of Marburg,Skåne University Hospital
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- Almquist, Martin (författare)
- Lund University,Lunds universitet,Endokrin- och sarkomkirurgi,Forskargrupper vid Lunds universitet,Endocrine and Sarcoma Surgery,Lund University Research Groups,Skåne University Hospital
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- Bergenfelz, Anders (författare)
- Lund University,Lunds universitet,Endokrin- och sarkomkirurgi,Forskargrupper vid Lunds universitet,Endocrine and Sarcoma Surgery,Lund University Research Groups,Skåne University Hospital
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- Nordenström, Erik (författare)
- Lund University,Lunds universitet,Endokrin- och sarkomkirurgi,Forskargrupper vid Lunds universitet,Endocrine and Sarcoma Surgery,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2020-04-15
- 2020
- Engelska 7 s.
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Ingår i: Langenbeck's Archives of Surgery. - : Springer Science and Business Media LLC. - 1435-2443 .- 1435-2451. ; 405:2, s. 137-143
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose: Surgery is recommended for most patients with gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NENs). Rates of complications and perioperative mortality have been reported in few mostly retrospective single-center series, but there has been no detailed analysis on risk factors for perioperative complications and mortality to date. Methods: Data of patients with GEP-NENs operated between January 2015 and September 2018 were retrieved from EUROCRINE©, a European online endocrine surgical quality registry, and analyzed regarding rate and risk factors of surgical complications. Risk factors were assessed by logistic regression. Results: Some 376 patients (211 female, 167 male; age median 63, range 15–89 years) were included. Most NENs were located in the small intestine (SI) (n = 132) or pancreas (n = 111), the rest in the stomach (n = 34), duodenum (n = 30), appendix (n = 30), colon, and rectum (n = 22), or with unknown primary (n = 15). Of the tumors, 320 (85.1%) were well or moderately differentiated, and 147 (39.1%) of the patients had distant metastases at the time of operation. Severe complications (Dindo-Clavien ≥ 3) occurred in 56 (14.9%) patients, and 4 (1.1%) patients died perioperatively. Severe complications were more frequent in surgery for duodenopancreatic NENs (n = 31; 22.0%) compared with SI-NENs (n = 15; 11.4%) (p = 0.014), in patients with lymph node metastases operated with curative aim of surgery (n = 24; 21.4%) versus non-metastasized tumors or palliative surgery (n = 32; 12.1%) (p = 0.020), and in functioning tumors (n = 20; 23.0%) versus non-functioning tumors (n = 30; 13.5%) (p = 0.042). Complication rates were not significantly associated with tumor stage or grade. Conclusions: Severe complications are frequent in GEP-NEN surgery. Besides duodenopancreatic tumor location, curative resection of nodal metastases and functioning tumors are risk factors for complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Gastro-entero-pancreatic system
- Neuroendocrine neoplasia
- Pancreas
- Perioperative complications
- Small intestine
- Surgery
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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