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Drug prescriptions preceding opioid-related deaths – a register study in forensic autopsy patients
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- Walde, Jonatan (författare)
- Umeå universitet,Umeå University,Institutionen för klinisk mikrobiologi,Umeå University and Region Västerbotten, Umeå, Sweden
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- Andersson, Lisa (författare)
- Malmö universitet,Malmö University,Faculty of Health and Society, Department of Social Work, Malmö University, Malmö, Sweden,Institutionen för socialt arbete (SA)
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- Johnson, Björn (författare)
- Malmö universitet,Lund University,Lunds universitet,Missbruk och beroende,Socialhögskolan,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Addiction Research,School of Social Work,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences,Faculty of Health and Society, Department of Social Work, Malmö University, Malmö, Sweden; Lund University, School of Social Work, Lund, Sweden,Institutionen för socialt arbete (SA)
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- Håkansson, Anders C (författare)
- Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för klinisk beroendeforskning,Forskargrupper vid Lunds universitet,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical addiction research unit,Lund University Research Groups,Department of Clinical Sciences Lund, Lund University, Psychiatry, Lund, Sweden; Malmö Addiction Center, Region Skåne, Malmö, Sweden
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(creator_code:org_t)
- Public Library of Science (PLoS), 2023
- 2023
- Engelska 18 s.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 18:5, s. 1-1
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background/AimOpioid overdose deaths have increased in Sweden and other developed countries in recent decades, despite increased treatment efforts and harm-reduction interventions. Further knowledge in this field is needed if this trend is to be reversed. Previous research suggests that mental health and patterns of prescription of opioids and other prescription drugs are associated with increased opioid-related mortality. The present study therefore aimed to investigate what drugs were prescribed during the last six months of life to individuals with a history of illicit substance use who died with opioids present in their blood, the relationship between drugs prescribed and drugs found in blood at time of death, and if prescription of specific drugs was temporally associated with death.MethodsThis was a retrospective, register-based observational study that utilized data from the National Board of Forensic Medicine, the Prescribed Drug Registry, regional health care services, and municipal social services. We used conditional logistic regression to find temporal associations between the prescription and dispensing of drugs and time of death.ResultsPrescription and dispensing of alprazolam and diazepam were temporally associated with death. The most frequently dispensed drugs were zopiclone, pregabalin, methylphenidate, diazepam and oxycodone. Methadone, alprazolam, and buprenorphine were the drugs most often found in the blood. Opioids and tranquilizers in combination were found in a vast majority of deaths, and prescription data suggested that the use of these drugs was illicit in a majority of cases.ConclusionPrescription of certain drugs, especially alprazolam and diazepam, should be made with great caution to patients with a history of illicit substance use or concurrent use of opioids.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
Publikations- och innehållstyp
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