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Quantifying rates o...
Quantifying rates of HIV-1 flow between risk groups and geographic locations in Kenya : A country-wide phylogenetic study
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- Nduva, George M. (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
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- Otieno, Frederick (author)
- Nyanza Reproductive Health Society
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- Kimani, Joshua (author)
- University of Nairobi,University of Manitoba
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- Wahome, Elizabeth (author)
- Kenya Medical Research Institute (KEMRI)
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- McKinnon, Lyle R. (author)
- University of Manitoba,University of Nairobi,University of KwaZulu-Natal
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- Cholette, Francois (author)
- University of Manitoba
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- Majiwa, Maxwell (author)
- Kenya Medical Research Institute (KEMRI)
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- Masika, Moses (author)
- University of Nairobi
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- Mutua, Gaudensia (author)
- University of Nairobi
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- Anzala, Omu (author)
- University of Nairobi
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- Graham, Susan M. (author)
- Kenya Medical Research Institute (KEMRI),University of Washington
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- Gelmon, Larry (author)
- University of Nairobi,University of Manitoba
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- Price, Matt A. (author)
- University of California, San Francisco
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- Smith, Adrian D. (author)
- University of Oxford
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- Bailey, Robert C. (author)
- Nyanza Reproductive Health Society,University of Illinois at Chicago
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- Baele, Guy (author)
- Catholic University of Leuven
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- Lemey, Philippe (author)
- Catholic University of Leuven
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- Hassan, Amin S. (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
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- Sanders, Eduard J. (author)
- Kenya Medical Research Institute (KEMRI),University of Oxford
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- Esbjörnsson, Joakim (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
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(creator_code:org_t)
- 2022-03-03
- 2022
- English.
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In: Virus Evolution. - : Oxford University Press (OUP). - 2057-1577. ; 8:1
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In Kenya, HIV-1 key populations including men having sex with men (MSM), people who inject drugs (PWID) and female sex workers (FSW) are thought to significantly contribute to HIV-1 transmission in the wider, mostly heterosexual (HET) HIV-1 transmission network. However, clear data on HIV-1 transmission dynamics within and between these groups are limited. We aimed to empirically quantify rates of HIV-1 flow between key populations and the HET population, as well as between different geographic regions to determine HIV-1 'hotspots' and their contribution to HIV-1 transmission in Kenya. We used maximum-likelihood phylogenetic and Bayesian inference to analyse 4058 HIV-1 pol sequences (representing 0.3 per cent of the epidemic in Kenya) sampled 1986-2019 from individuals of different risk groups and regions in Kenya. We found 89 per cent within-risk group transmission and 11 per cent mixing between risk groups, cyclic HIV-1 exchange between adjoining geographic provinces and strong evidence of HIV-1 dissemination from (i) West-to-East (i.e. higher-to-lower HIV-1 prevalence regions), and (ii) heterosexual-to-key populations. Low HIV-1 prevalence regions and key populations are sinks rather than major sources of HIV-1 transmission in Kenya. Targeting key populations in Kenya needs to occur concurrently with strengthening interventions in the general epidemic.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- HIV-1
- key populations
- molecular epidemiology
- transmission
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Nduva, George M.
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Otieno, Frederic ...
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Kimani, Joshua
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Wahome, Elizabet ...
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McKinnon, Lyle R ...
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Cholette, Franco ...
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show more...
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Majiwa, Maxwell
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Masika, Moses
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Mutua, Gaudensia
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Anzala, Omu
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Graham, Susan M.
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Gelmon, Larry
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Price, Matt A.
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Smith, Adrian D.
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Bailey, Robert C ...
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Baele, Guy
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Lemey, Philippe
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Hassan, Amin S.
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Sanders, Eduard ...
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Esbjörnsson, Joa ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Virus Evolution
- By the university
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Lund University