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A fibrin biofilm covers blood clots and protects from microbial invasion

Macrae, Fraser L. (author)
University of Leeds
Duval, Cédric (author)
University of Leeds
Papareddy, Praveen (author)
Lund University,Lunds universitet,Host parasite interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups
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Baker, Stephen R. (author)
University of Leeds
Yuldasheva, Nadira (author)
University of Leeds
Kearney, Katherine J. (author)
University of Leeds
McPherson, Helen R. (author)
University of Leeds
Asquith, Nathan (author)
University of Leeds
Konings, Joke (author)
Maastricht University Medical Centre
Casini, Alessandro (author)
Geneva University Hospital
Degen, Jay L. (author)
Cincinnati Children's Hospital Medical Center
Connell, Simon D. (author)
University of Leeds
Philippou, Helen (author)
University of Leeds
Wolberg, Alisa S. (author)
University of North Carolina
Herwald, Heiko (author)
Lund University,Lunds universitet,Host parasite interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups
Ariëns, Robert A.S. (author)
Maastricht University,University of Leeds
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 (creator_code:org_t)
2018
2018
English 13 s.
In: Journal of Clinical Investigation. - 0021-9738. ; 128:8, s. 3356-3368
Related links:
http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a characteristic network, interact with blood cells, and initiate tissue repair. The fibrin network is porous and highly permeable, but the spatial arrangement of the external clot face is unknown. Here we show that fibrin transitioned to the blood-air interface through Langmuir film formation, producing a protective film confining clots in human and mouse models. We demonstrated that only fibrin is required for formation of the film, and that it occurred in vitro and in vivo. The fibrin film connected to the underlying clot network through tethering fibers. It was digested by plasmin, and formation of the film was prevented with surfactants. Functionally, the film retained blood cells and protected against penetration by bacterial pathogens in a murine model of dermal infection. Our data show a remarkable aspect of blood clotting in which fibrin forms a protective film covering the external surface of the clot, defending the organism against microbial invasion.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

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art (subject category)
ref (subject category)

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